OCT4: A penetrant pluripotency inducer

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2014-01-01 DOI:10.1186/2045-9769-3-6

Xuecong Wang , Ralf Jauch

引用次数: 8

Abstract

Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.

Abstract Image

查看原文本刊更多论文

OCT4:一种渗透性多能诱导剂

天然OCT4蛋白具有穿越细胞膜进入细胞的内在能力。这一发现可能会重振用蛋白质代替基于核酸的方法诱导多能性的努力，并提出一个有趣的问题，即OCT4是否可以非细胞自主地起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine