Composite chromophobe renal cell carcinoma with sarcomatoid differentiation containing osteosarcoma, chondrosarcoma, squamous metaplasia and associated collecting duct carcinoma: a case report.

IF 0.1 4区医学 Q4 Medicine

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2014-08-01

Arjumand Husain, Bernhard J Eigl, Kiril Trpkov

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引用次数: 0

Abstract

Background: Chromophobe renal cell carcinoma (ChRCC) is a morphologically distinct renal cell carcinoma type which may rarely show composite morphology.

Case: A 61-year-old man presented with a composite ChRCC with sarcomatoid transformation containing osteosarcomatous, chondrosarcomatous and squamous metaplastic differentiation and associated with a high-grade collecting duct carcinoma (CDC). The patient presented with a metastatic disease in the regional lymph nodes, comprised only of CDC, and died after 21 months.

Conclusion: Although ChRCC associated with sarcomatoid change has been well documented, the presence of osteosarcoma has been previously reported in only 5 ChRCCs, 2 of which also contained chondrosarcoma. Squamous differentiation has been previously found in only 2 ChRCCs with sarcomatoid change, and ChRCC associated with CDC has been previously reported in only 3 cases, but none with heterologous elements. To our knowledge this represents a previously unreported composite type of RCC, with an aggressive clinical behavior.

本刊更多论文

复合憎色性肾细胞癌伴肉瘤样分化，包括骨肉瘤、软骨肉瘤、鳞状化生及相关集管癌1例。

背景:嫌色性肾细胞癌(ChRCC)是一种形态独特的肾细胞癌，很少表现为复合形态。病例:一名61岁男性，表现为复合ChRCC伴肉瘤样转化，包括骨肉瘤、软骨肉瘤和鳞状化生分化，并伴有高级别集管癌(CDC)。患者表现为局部淋巴结转移性疾病，仅由CDC组成，21个月后死亡。结论:尽管ChRCC与肉瘤样改变相关的文献已经得到了很好的记载，但之前仅报道了5例ChRCC中存在骨肉瘤，其中2例还包含软骨肉瘤。既往仅在2例伴有肉瘤样改变的ChRCC中发现鳞状分化，既往仅报道了3例与CDC相关的ChRCC，但均未发现异源因子。据我们所知，这代表了一种以前未报道的复合型RCC，具有侵略性的临床行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical and Quantitative Cytopathology and Histopathology CELL BIOLOGY-

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审稿时长

1 months

期刊介绍： AQCH is an Official Periodical of The International Academy of Cytology and the Italian Society of Urologic Pathology.