A Comparative Study between Olanzapine and Risperidone in the Management of Schizophrenia.

IF 3.6 Q1 PSYCHIATRY
Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-08-26 DOI:10.1155/2014/307202
Saeed Shoja Shafti, Mahsa Gilanipoor
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引用次数: 14

Abstract

Introduction. Since a variety of comparisons between risperidone and olanzapine have resulted in diverse outcomes, so safety and efficacy of them were compared again in a new trial. Method. Sixty female schizophrenic patients entered into one of the assigned groups for random allocation to olanzapine or risperidone (n = 30 in each group) in a double-blind, 12-week clinical trial. Scale for Assessment of Positive Symptoms (SAPS) and Scale for Assessment of Negative Symptoms (SANS) were used as the primary outcome measures. Clinical Global Impressions-Severity Scale (CGI-S), Schedule for Assessment of Insight (SAI), and finally Simpson Angus Scale (SAS) as well were employed as secondary scales. Results. While both of olanzapine and risperidone were significantly effective for improvement of positive symptoms (P < 0.0001), as regards negative symptoms, it was so only by means of olanzapine (P < 0.0003). CGI-S and SAI, as well, were significantly improved in both of the groups. SAS increment was significant only in the risperidone group (P < 0.02). Conclusion. While both of olanzapine and risperidone were equally effective for improvement of positive symptoms and insight, olanzapine showed superior efficacy with respect to negative symptoms, along with lesser extrapyramidal side effects, in comparison with risperidone.

奥氮平与利培酮治疗精神分裂症的比较研究。
介绍。由于利培酮和奥氮平的各种比较结果不同,因此在新的试验中再次比较了它们的安全性和有效性。方法。60名女性精神分裂症患者进入指定组,随机分配至奥氮平或利培酮组(每组30人),进行为期12周的双盲临床试验。阳性症状评估量表(SAPS)和阴性症状评估量表(SANS)被用作主要结果测量。辅助量表采用临床总体印象严重程度量表(CGI-S)、洞察力评估量表(SAI)和辛普森安格斯量表(SAS)。结果。奥氮平和利培酮对阳性症状的改善均有显著效果(P < 0.0001),而对阴性症状的改善,仅奥氮平有效(P < 0.0003)。两组的CGI-S和SAI均有明显改善。SAS仅在利培酮组有显著升高(P < 0.02)。结论。虽然奥氮平和利培酮对改善阳性症状和顿见同样有效,但与利培酮相比,奥氮平对阴性症状的疗效更佳,锥体外系副作用更小。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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