P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue.

Q2 Medicine

BMC Clinical Pathology Pub Date : 2014-08-09 eCollection Date: 2014-01-01 DOI:10.1186/1472-6890-14-37

Raju Adduri, Viswakalyan Kotapalli, Neha A Gupta, Swarnalata Gowrishankar, Mukta Srinivasulu, Mohammed Mujtaba Ali, Subramanyeshwar Rao, Shantveer G Uppin, Umanath K Nayak, Snehalatha Dhagam, Mohana Vamsy Chigurupati, Murali Dharan Bashyam

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引用次数: 14

Abstract

Background: Squamous cell carcinoma of tongue (SCCT) is expected to harbor unique clinico-pathological and molecular genetic features since a significant proportion of patients are young and exhibit no association with tobacco or alcohol.

Methods: We determined P53, epidermal growth factor receptor, microsatellite instability, human papilloma virus infection and loss of heterozygosity status at several tumor suppressor loci in one hundred and twenty one oral SCCT (SSCOT) samples and analyzed their association with clinico-pathological features and patient survival.

Results: Our results revealed a significantly higher incidence of p53 nuclear stabilization in early (as against late) onset SCCOT. FHIT loss was significantly associated with p53 nuclear stabilization and the association was stronger in patients with no history of tobacco use. Samples harboring mutation in p53 DNA binding domain or exhibiting p53 nuclear stabilization, were significantly associated with poor survival.

Conclusion: Our study has therefore identified distinct features in SCCOT tumorigenesis with respect to age and tobacco exposure and revealed possible prognostic utility of p53.

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在口腔舌鳞癌中，P53核稳定与FHIT丢失和发病年龄年轻相关。

背景:舌头鳞状细胞癌(SCCT)被认为具有独特的临床病理和分子遗传学特征，因为相当大比例的患者是年轻的，并且与烟草或酒精无关。方法:我们检测了121例口腔SCCT (SSCOT)样本中P53、表皮生长因子受体、微卫星不稳定性、人乳头瘤病毒感染和几种肿瘤抑制位点杂合性缺失的情况，并分析了它们与临床病理特征和患者生存的关系。结果:我们的研究结果显示，早期(相对于晚期)SCCOT的p53核稳定发生率明显更高。FHIT缺失与p53核稳定显著相关，且在无烟草使用史的患者中相关性更强。携带p53 DNA结合域突变或显示p53核稳定的样本与较差的生存率显著相关。结论:因此，我们的研究确定了SCCOT肿瘤发生与年龄和烟草暴露相关的独特特征，并揭示了p53可能的预后效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Clinical Pathology Medicine-Pathology and Forensic Medicine

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.