Evolutionary theories of aging can explain why we age.

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI:10.1159/000358897
Eric Le Bourg
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引用次数: 18

Abstract

Evolutionary theories of aging explain why we age. These theories take into account the fact that, in the wild, mean lifespan of many species is usually shorter than it could be in protected environments. In such conditions, because most of animals die before reaching old age, there is no selection in favor or against alleles with effects at old age. Alleles with negative effects at this age can thus accumulate in successive generations, particularly if they also have positive effects at young age and are thus retained by selection. This chapter describes the evolutionary theories of aging and their consequences for the understanding of the biology of aging as well as the challenges to these theories. It is argued that these theories offer a reasonable explanation to the existence of the aging process even if they can surely be refined.

衰老的进化理论可以解释我们衰老的原因。
衰老的进化理论解释了我们衰老的原因。这些理论考虑到这样一个事实,即在野外,许多物种的平均寿命通常比在受保护的环境中要短。在这种情况下,因为大多数动物在衰老之前就死亡了,所以没有选择对衰老时有影响的等位基因有利或不利。因此,在这个年龄具有负面影响的等位基因可以在后代中积累,特别是如果它们在年轻时也具有积极影响,并因此通过选择而保留下来。本章描述了衰老的进化理论及其对理解衰老生物学的影响,以及对这些理论的挑战。有人认为,这些理论为衰老过程的存在提供了合理的解释,即使它们肯定可以被改进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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