The aetiology of delay to commencement of adjuvant chemotherapy following colorectal resection.

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2014-01-01 Epub Date: 2014-03-17 DOI:10.1155/2014/670212
G S Simpson, R Smith, P Sutton, A Shekouh, C McFaul, M Johnson, D Vimalachandran
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引用次数: 13

Abstract

Purpose: Timely administration of adjuvant chemotherapy following colorectal resection is associated with improved outcome. We aim to assess the factors which are associated with delay to adjuvant chemotherapy in patients who underwent colorectal resection as part of an enhanced recovery protocol.

Method: A univariate and multivariate analysis of patient data collected as part of a prospectively maintained database of colorectal cancer patients between 2007 and 2012.

Results: 166 patients underwent colorectal resection followed by adjuvant chemotherapy. Median postoperative hospital stay was 6 days, and time to commencement of adjuvant chemotherapy was 50 days. Longer inpatient stay correlated with increased time to adjuvant chemotherapy (P = 0.05). Factors found to be independently associated with duration of hospital stay and time to commencement of adjuvant chemotherapy included stoma formation (P = 0.032), anastaomotic leak (P = 0.027), and preoperative albumin (P = 0.027). The use of laparoscopic surgery was associated with shorter time to adjuvant chemotherapy but did not reach significance (P = 0.143).

Conclusion: A number of independent variables associated with delay to adjuvant therapy previously not described have been identified. Further work may be required to elucidate the effect that these variables have on long-term outcome.

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结直肠癌术后延迟开始辅助化疗的原因分析。
目的:结直肠切除术后及时给予辅助化疗可改善预后。我们的目的是评估在接受结肠直肠癌切除术作为增强恢复方案的一部分的患者中延迟辅助化疗的相关因素。方法:对2007年至2012年结肠直肠癌患者前瞻性数据库中收集的患者数据进行单因素和多因素分析。结果:166例患者行结肠切除术后辅助化疗。术后中位住院时间为6天,至开始辅助化疗时间为50天。住院时间越长,辅助化疗时间越长(P = 0.05)。与住院时间和辅助化疗开始时间独立相关的因素包括造口形成(P = 0.032)、吻合口漏(P = 0.027)和术前白蛋白(P = 0.027)。腹腔镜手术的使用与辅助化疗时间缩短相关,但没有达到显著性(P = 0.143)。结论:许多与辅助治疗延迟相关的独立变量之前没有被描述过。可能需要进一步的工作来阐明这些变量对长期结果的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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