Targeted therapy in gastrointestinal malignancies.

Q1 Environmental Science

Journal of Carcinogenesis Pub Date : 2014-02-20 eCollection Date: 2014-01-01 DOI:10.4103/1477-3163.127639

Ravi Chhatrala, Yasmin Thanavala, Renuka Iyer

引用次数: 8

Abstract

Increased understanding of cancer pathogenesis has identified several pathways that serve as potential targets for novel targeted agents in development. The selection of targeted cancer therapy based on biomarkers has instigated a new era of personalized medicine and changed the way we practice oncology. Many targeted agents are approved for treatment of gastrointestinal malignancies most targeting tumor angiogenesis, and many more are in different phases of development. Here we briefly summarize nine different targeted agents that are approved currently in the U.S. and several other agents currently being studied in various gastrointestinal cancers.

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胃肠道恶性肿瘤的靶向治疗。

对癌症发病机制的进一步了解已经确定了几种途径，作为正在开发的新型靶向药物的潜在靶点。基于生物标志物的靶向癌症治疗的选择已经开启了个性化医疗的新时代，并改变了我们实践肿瘤学的方式。许多靶向药物被批准用于治疗胃肠道恶性肿瘤，大多数靶向肿瘤血管生成，还有更多的药物处于不同的发展阶段。在这里，我们简要地总结了目前在美国批准的九种不同的靶向药物以及目前正在研究的几种用于各种胃肠道癌症的其他药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Carcinogenesis Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

7.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. Primary areas of interest to the journal include: physical and chemical carcinogenesis and mutagenesis; processes influencing or modulating carcinogenesis, such as DNA repair; genetics, nutrition, and metabolism of carcinogens; the mechanism of action of carcinogens and modulating agents; epidemiological studies; and, the formation, detection, identification, and quantification of environmental carcinogens. Manuscripts that contribute to the understanding of cancer prevention are especially encouraged for submission