Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China.

H Wan, J Wu, P Sun, Yuelin Yang
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引用次数: 12

Abstract

Unlabelled: This study is to explore the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers.

Methods: We conducted a cross-sectional study on 156 workers with occupational exposure to lead between 2002 and 2007. The results of laboratory examinations were analyzed.

Results: The authors found that workers with the ALAD 1-1 genotype were associated with higher blood lead level than those with the ALADl-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The urine ALA and blood ZPP levels in workers with the ALAD 1-1 genotype were higher than those with the ALADl-2 genotype. The serum Cr level in workers with the ALADl-1 genotype was much higher than those with the ALADl-2 genotype especially in higher lead exposure level.

Conclusions: The ALAD-2 protein might modify the kinetics of lead in blood at a relatively higher blood lead level and protect against hematopoietic, hepatic and renal toxicity from lead. Urine ALA, blood ZPP and serum Cr levels might be considered as effective biological monitoring partners of lead induced hematopoietic and renal toxicology.

影响西南汉族铅致造血、肝、肾毒性的δ -氨基乙酰丙酸脱水酶多态性研究。
未标记:本研究旨在探讨ALAD多态性对职业性铅暴露工人造血、肝和肾毒性的影响。方法:对2002年至2007年间156名职业性铅暴露工人进行了横断面研究。对实验室检查结果进行分析。结果:作者发现alad1 -1基因型的工人血铅水平高于ALADl-2基因型的工人。蓄电池工人血液和尿液中的铅含量比电缆工人高得多。alad1 -1基因型工人尿ALA和血ZPP水平高于ALADl-2基因型工人。ALADl-1基因型工人血清Cr水平明显高于ALADl-2基因型工人,特别是在高铅暴露水平时。结论:ALAD-2蛋白可能在较高血铅水平下改变血铅动力学,对铅的造血、肝和肾毒性具有保护作用。尿ALA、血ZPP和血清Cr水平可作为铅诱导的造血和肾毒理学的有效生物监测伙伴。
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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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