Design of spherical agglomerates via crystallization with a non-toxic bridging liquid: From mechanism to application

IF 4.6 2区工程技术 Q2 ENGINEERING, CHEMICAL

Powder Technology Pub Date : 2022-08-01 DOI:10.1016/j.powtec.2022.117725

Shilin Guo , Shanshan Feng , Changyou Yu , Yanbo Liu , Kangli Li , Mingyang Chen , Dandan Han , Junbo Gong

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引用次数: 7

Abstract

The cooling crystallization-spherical agglomeration (CCSA) technology proposed in this work overcomes the disadvantages of complex process and biohazardous solvents, which has broad application prospects in green and efficient granulation. CCSA selects oleic acid as a novel green and effective bridging liquid, and the results of droplet experiment and molecular simulation indicate that oleic acid presents the best wetting performance compared with the reported bridging liquids. Mechanistic studies demonstrate that oleic acid can induce spherical agglomeration during crystallization in a single solvent system, especially in water, reducing the dosage of organic solvent by about 90%, and fundamentally eliminating the toxicity of bridging liquid. The volume ratio of bridging liquid to solvent (RBS) and agitation are emphasized as the critical parameters tuning the particle size and sphericity. Further, the spherical agglomerates of benzoic acid, L-leucine and aspirin with controllable size and high sphericity were successfully prepared, which verifies the universality of CCSA.

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用无毒桥接液结晶球形团块的设计:从机理到应用

本文提出的冷却结晶-球形团聚(CCSA)技术克服了工艺复杂和使用生物有害溶剂的缺点，在绿色高效造粒方面具有广阔的应用前景。CCSA选择油酸作为新型绿色高效的桥接液，液滴实验和分子模拟结果表明，与已有的桥接液相比，油酸具有最佳的润湿性能。机理研究表明，油酸在单一溶剂体系中，特别是在水中，结晶过程中可诱导球形团聚，使有机溶剂的用量减少约90%，从根本上消除桥接液的毒性。强调桥接液与溶剂的体积比和搅拌是调节颗粒大小和球度的关键参数。成功制备了粒径可控、球形度高的苯甲酸、l -亮氨酸和阿司匹林球状团聚体，验证了CCSA的通用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.