Innate immunity and the role of the antimicrobial peptide cathelicidin in inflammatory skin disease

Keith D. Roby, Anna Di Nardo
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引用次数: 26

Abstract

Cathelicidin antimicrobial peptide is an important mediator of the innate immune response. In addition to its potent antimicrobial activity, cathelicidin has been shown to have chemoattractant and angiogenic properties. Recent research has demonstrated that, in addition to its aforementioned functions, cathelicidin plays an important role in the complex pathogenesis of several chronic inflammatory skin diseases. This review will present a concise overview of the role of cathelicidin in infection and in the development of atopic dermatitis, psoriasis and rosacea. This understanding will direct future research efforts to identify therapeutic approaches that use cathelicidin as a novel drug itself, or aim to modify its expression and regulation.

天然免疫及抗菌肽抗菌肽在炎症性皮肤病中的作用
抗菌肽是先天免疫应答的重要介质。除了其有效的抗菌活性外,抗菌肽已被证明具有化学引诱剂和血管生成特性。最近的研究表明,除了上述功能外,cathelicidin在多种慢性炎症性皮肤病的复杂发病机制中起着重要作用。这篇综述将简要介绍抗菌肽在感染和特应性皮炎、牛皮癣和酒渣鼻的发展中的作用。这一认识将指导未来的研究工作,以确定使用cathelicidin作为新药本身的治疗方法,或旨在修改其表达和调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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