Adult mesenchymal stem cells and their potency in the cell-based therapy.

Q4 Biochemistry, Genetics and Molecular Biology
Journal of Stem Cells Pub Date : 2013-01-01
Madhurima Das, Inger Birgitta Sundell, Prasad S Koka
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引用次数: 0

Abstract

Recent advances in the field of regenerative medicines manifested the unique properties of stem cells including the ability of self-renewal and differentiation to make them available for their replacement in tissue injury. Mesenchymal stem cells (MSCs) are important tools in treating immune disorders and in tissue repair due to their multipotency, immunosuppressive properties, and production of cytokines or growth factors. MSC-mediated therapy is a fast-growing field that has proven safe and effective in the treatment of various degenerative diseases and tissue injuries. Generation of induced pluripotent stem (iPS) cells holds a great promise for regenerative medicine and other aspects of clinical applications. The mechanisms governing multipotency in MSCs are not well understood. This review mainly throws light on the biology of MSCs, including their efficiency in treating several diseases and also the progress of the use of iPSC-derived MSC widely in the clinic.

成体间充质干细胞及其在细胞治疗中的作用。
再生医学领域的最新进展表明干细胞的独特特性,包括自我更新和分化的能力,使它们可以在组织损伤中替代。间充质干细胞(MSCs)由于其多能性、免疫抑制特性和产生细胞因子或生长因子而成为治疗免疫疾病和组织修复的重要工具。msc介导的治疗是一个快速发展的领域,在治疗各种退行性疾病和组织损伤方面已被证明是安全有效的。诱导多能干细胞的产生在再生医学和其他临床应用方面具有很大的前景。控制MSCs多能性的机制尚不清楚。本文主要综述了间充质干细胞的生物学特性,包括其治疗多种疾病的功效,以及ipsc衍生的间充质干细胞在临床中的广泛应用进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Stem Cells
Journal of Stem Cells Medicine-Transplantation
CiteScore
0.10
自引率
0.00%
发文量
1
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