Hyperhomocysteinemia and hyperlipoproteinemia (a) in obese South Indian men: an indication for increased cardiovascular risk.

S Ikkruthi, Medha Rajappa, H Nandeesha, S Satheesh, I Sundar, P H Ananthanarayanan, K T Harichandrakumar
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引用次数: 5

Abstract

Obesity is a pathological condition which increases the risk for cardiovascular disease. The present study was designed to evaluate homocysteine, lipoprotein (a) [Lp(a)], apolipoprotein-B (apo-B), apolipoprotein-A-I (apo-A-I) and lipid indices and their association if any in obese South Indian men. Thirty obese men and thirty age-matched males with normal body weight (controls) were recruited in the study. Plasma homocysteine, Lp(a), lipid profile, apo-A-I and apo-B were estimated in all the subjects. Lipid indices such as lipid pentad index (LPI), lipid tetrad index (LTI), atherogenic index of plasma (AIP), non-high density lipoprotein (non-HDL)/high density lipoprotein (HDL) ratio and apo-B/apo-A-I ratio were calculated in all study subjects. Homocysteine, Lp(a), apo-B, apo-B/apo-A-I ratio and lipid indices were significantly increased in obese men, compared to controls. Both homocysteine and Lp(a) were positively correlated with BMI, waist, hip circumference and apo-B and negatively correlated with apo-A-I. Also we found highly significant positive correlation between homocysteine and Lp(a) levels. The data from the present study concludes that non-conventional risk factors like homocysteine, Lp (a), apo-B/apo-A-I ratio, LTI, LPI, non-HDL/HDL ratio and AIP were significantly elevated in obese Indian men, suggesting they are more prone to develop cardiovascular disease, than the age-matched men with normal body weight.

南印度肥胖男性的高同型半胱氨酸血症和高脂蛋白血症(a):心血管风险增加的指征
肥胖是一种病理状态,会增加患心血管疾病的风险。本研究旨在评估南印度肥胖男性的同型半胱氨酸、脂蛋白(a) [Lp(a)]、载脂蛋白- b (apo-B)、载脂蛋白- a - i (apo-A-I)和脂质指数及其相关性。研究招募了30名肥胖男性和30名体重正常的同龄男性(对照组)。对所有受试者进行血浆同型半胱氨酸、Lp(a)、血脂、载脂蛋白a - i和载脂蛋白b的测定。计算所有受试者的脂质指数,如脂质五分体指数(LPI)、脂质四分体指数(LTI)、血浆致动脉粥样硬化指数(AIP)、非高密度脂蛋白(non-HDL)/高密度脂蛋白(HDL)比值和载脂蛋白b /载脂蛋白a - i比值。与对照组相比,肥胖男性的同型半胱氨酸、Lp(a)、载脂蛋白b、载脂蛋白b /载脂蛋白a - i比值和脂质指数显著升高。同型半胱氨酸和Lp(a)与BMI、腰围、臀围和载脂蛋白b呈正相关,与载脂蛋白a - i呈负相关。我们还发现同型半胱氨酸与Lp(a)水平呈极显著正相关。本研究数据表明,印度肥胖男性的同型半胱氨酸、Lp (a)、载脂蛋白b /载脂蛋白a - i比值、LTI、LPI、非高密度脂蛋白/高密度脂蛋白比值、AIP等非传统危险因素显著升高,表明印度肥胖男性比同龄正常体重男性更容易发生心血管疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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6.0 months
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