Oxidative stress in blood and testicle of rat following intraperitoneal administration of aluminum and indium.

S Maghraoui, Simona Clichici, A Ayadi, C Login, R Moldovan, D Daicoviciu, N Decea, A Mureşan, L Tekaya
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引用次数: 8

Abstract

Aluminum (Al) and indium (In) have embryotoxic, neurotoxic and genotoxic effects, oxidative stress being one of the possible mechanisms involved in their cytotoxicity. We have recently demonstrated that indium intraperitoneal (ip) administration induced histological disorganization of testicular tissue. In the present research we aimed at investigating the effect of Al and In ip administration on systemic and testicular oxidative stress status. Studies were performed on Wistar rats ip injected with Al, In or physiological solution for two weeks. Our results showed that In significantly decreased the absolute weight of testicles. Measurements of lactate dehydrogenase (LDH) and paraoxonase (PON) activities showed that In induced a significant augmentation in the first parameter but no changes were observed in the second. Both Al and In caused oxidative stress in testicles by increasing malondialdehyde (MDA) and protein carbonyls (PC) production. Concomitantly, thiol group (-SH) and glutathione (GSH) level were enhanced in the testicles. In the blood, while concentrations of MDA was not changed, those of GSH was significantly decreased in the Al and In groups. Our results indicated that Al and In cause oxidative stress both in blood and testicles but In has cytotoxic effect as well as negative impact on testicle weights. These findings could explain the testicular histological alterations previously described after In ip administration.

腹腔注射铝和铟后大鼠血液和睾丸氧化应激的变化。
铝(Al)和铟(In)具有胚胎毒性、神经毒性和遗传毒性,氧化应激可能是其细胞毒性的机制之一。我们最近证明,腹腔注射铟(ip)诱导睾丸组织的组织学紊乱。在本研究中,我们旨在探讨Al和In的给药对全身和睾丸氧化应激状态的影响。Wistar大鼠分别注射Al、In或生理溶液两周。我们的研究结果表明,In显著降低了睾丸的绝对重量。乳酸脱氢酶(LDH)和对氧磷酶(PON)活性的测定表明,In显著提高了第一个参数,但对第二个参数没有影响。Al和In均通过增加丙二醛(MDA)和蛋白羰基(PC)的产生而引起睾丸氧化应激。同时,睾丸中硫醇组(-SH)和谷胱甘肽(GSH)水平升高。血中丙二醛(MDA)浓度无变化,而谷胱甘肽(GSH)浓度显著降低。我们的研究结果表明,Al和In在血液和睾丸中都引起氧化应激,但In具有细胞毒性作用,并对睾丸重量产生负面影响。这些发现可以解释先前在给药后描述的睾丸组织学改变。
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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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