Variation in urinary excretion of FDG, yet another uncertainty in quantitative PET.

Acta Radiologica Short Reports Pub Date : 2012-09-23 eCollection Date: 2012-01-01 DOI:10.1258/arsr.2012.120038

Tore Bach-Gansmo, Ja Dybvik, Tc Adamsen, A Naum

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引用次数: 16

Abstract

Background: The standardized uptake value (SUV) is the most common estimate of metabolic activity used in clinical positron emission tomography (PET). Several biological and technological factors influence the accurate SUV calculation.

Purpose: To assess another potential source of variability of the SUV, the variations in urinary excretion of fluorodeoxyglucose (FDG).

Material and methods: Twenty patients with various malignancies scheduled for PET/CT with 18F-FDG were included in the present study. The activity in urine voided immediately before image acquisition was measured and decay corrected. An estimation of FDG content in the urinary bladder was made during imaging, and the two components of urinary FDG were added. The urinary output of FDG, and the quantity of FDG divided by the time to measurements, was estimated.

Results: The excretion of FDG in urine was between 5.7% and 15.2% of injected dose (decay corrected), and from 0.06% to 0.3%/min after injection, a five-fold difference in clearance.

Conclusion: About 10% of injected dose is excreted in urine at 70 min post injection, but the urinary FDG excretion was found to be highly variable, yet another uncertainty affecting the SUV measurements.

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尿中FDG排泄的变化，定量PET的另一个不确定性。

背景:标准化摄取值(SUV)是临床正电子发射断层扫描(PET)中最常用的代谢活性估计。几个生物和技术因素影响SUV的精确计算。目的:评估SUV变异性的另一个潜在来源，尿中氟脱氧葡萄糖(FDG)排泄的变化。材料和方法:本研究纳入了20例不同恶性肿瘤的PET/CT检查，检查结果为18F-FDG。在图像采集之前立即测量尿液中的活性并校正衰减。在成像时估计膀胱中FDG的含量，并添加尿中FDG的两种成分。估计尿中FDG的排出量，以及FDG的量除以测量时间。结果:尿中FDG的排泄量为注射剂量的5.7% ~ 15.2%(衰减校正)，注射后为0.06% ~ 0.3%/min，清除率相差5倍。结论:约10%的注射剂量在注射后70分钟通过尿液排出，但尿中FDG的排出量变化很大，这是影响SUV测量的另一个不确定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Radiologica Short Reports

自引率

0.00%

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审稿时长

12 weeks

期刊介绍： Under the editorial leadership of Professor Arnulf Skjennald MD and a distinguished editorial board, Acta Radiologica Open, formerly Acta Radiologica Short Reports, aims for the prompt publication of original case reports, short reports, review articles, pictorial reviews, research articles on diagnostic and interventional radiology, clinical radiology, experimental investigations in animals, and all other research related to imaging procedures. Acta Radiologica Open provides a complete update on all radiological specialties and technical utilities, as well as physiology and physics related to imaging, including ultrasonography, computed tomography, radionuclide and magnetic resonance imaging. Acta Radiologica Open publishes articles on diagnostic and interventional procedures in radiology based on all medical imaging techniques, as well as works in physiology and physics when related to radiology. The journal is an online-only, peer reviewed, open access journal.