Relationships between Cerebral Blood Flow and IQ in Typically Developing Children and Adolescents.

IF 0.2 Q4 LINGUISTICS
Emily Kilroy, Collin Y Liu, Lirong Yan, Yoon Chun Kim, Mirella Dapretto, Mario F Mendez, Danny J J Wang
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引用次数: 26

Abstract

The objective of this study was to explore the relationships between IQ and cerebral blood flow (CBF) measured by arterial spin labeling (ASL) in children and adolescents. ASL was used to collect perfusion MRI data on 39 healthy participants aged 7 to 17. The Wechsler Abbreviated Intelligence Scale was administered to determine IQ scores. Multivariate regression was applied to reveal correlations between CBF and IQ scores, accounting for age, sex and global mean CBF. Voxel Based Morphometry (VBM) analysis, which measures regional cortical volume, was performed as a control. Regression analyses were further performed on CBF data with adjustment of regional gray matter density (GMD). A positive correlation between CBF and IQ scores was primarily seen in the subgenual/anterior cingulate, right orbitofrontal, superior temporal and right inferior parietal regions. An inverse relationship between CBF and IQ was mainly observed in bilateral posterior temporal regions. After adjusting for regional GMD, the correlations between CBF and IQ in the subgenual/anterior cingulate cortex, right orbitofrontal, superior temporal regions and left insula remained significant. These findings support the Parieto-Frontal Integration Theory of intelligence, especially the role of the subgenual/anterior cingulate cortex in the neural networks associated with intelligence. The present study also demonstrates the unique value of CBF in assessing brain-behavior relationships, in addition to structural morphometric measures.

典型发育儿童和青少年脑血流量与智商的关系
本研究旨在探讨儿童和青少年智商与动脉自旋标记(ASL)测量的脑血流量(CBF)之间的关系。使用ASL收集39名7 ~ 17岁健康受试者的灌注MRI数据。采用韦氏简略智力量表测定智商分数。考虑到年龄、性别和全球平均CBF,应用多元回归揭示CBF与智商分数之间的相关性。测量区域皮质体积的基于体素的形态测量(VBM)分析作为对照。校正区域灰质密度(GMD)后对CBF数据进行回归分析。脑血流与智商的正相关主要出现在亚属/前扣带区、右侧眶额区、颞上区和右侧下顶叶区。脑血流与智商主要在双侧后颞区呈负相关。在调整区域GMD后,亚属/前扣带皮层、右眼窝额叶、颞上区和左脑岛的CBF与智商之间的相关性仍然显著。这些发现支持智力的顶叶-额叶整合理论,特别是亚属/前扣带皮层在与智力相关的神经网络中的作用。除了结构形态测量外,本研究还证明了CBF在评估脑行为关系方面的独特价值。
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
0
期刊介绍: Journal of Cognitive Science is an official journal of the International Association for Cognitive Science (IACS, http://ia-cs.org) and published quarterly by the Institute for Cognitive Science at Seoul National University, located in Seoul, Korea. The Association currently consists of member societies of different countries such as Australia, China, Japan, Korea, and European Union. However, paper submission by anyone in the whole world is welcome at any time. Its main concern is to showcase research articles of highest quality and significance within the disciplines of cognitive science, including, but not limited to, philosophy, psychology, linguistics, artificial intelligence, neuroscience, aesthetics, anthropology, and education, insofar as it is deemed to be of interest to those who pursue the study of mind. In particular, we would like to encourage submissions that cross the traditional disciplinary boundaries. The Journal of Cognitive Science (JCS) is published quarterly on 31 March, 30 June, 30 September, 31 December (founded in 2000) as the official journal of International Association for Cognitive Science (IACS) by the Institute for Cognitive Science at Seoul National University. It is a SCOPUS, ESCI, EBSCO, KCI journal. It aims to publish research articles of the highest quality and significance within the disciplines that form cognitive science, including philosophy, psychology, linguistics, artificial intelligence, neuroscience, anthropology, and education for Interdisciplinary Journal. Submissions that cross traditional disciplinary boundaries in either themes or methods are especially encouraged. AI-associated Cognitive Science will be newly reinforced and papers in this area are encouraged to be submitted.
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