Association between alkaline phosphatase and hypertension in a rural Japanese population: the Nagasaki Islands study.

IF 3.3 4区医学 Q1 PHYSIOLOGY

Journal of Physiological Anthropology Pub Date : 2013-06-27 DOI:10.1186/1880-6805-32-10

Yuji Shimizu, Mio Nakazato, Takaharu Sekita, Koichiro Kadota, Hironori Yamasaki, Noboru Takamura, Kiyoshi Aoyagi, Yosuke Kusano, Takahiro Maeda

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引用次数: 0

Abstract

Background: Although serum alkaline phosphatase (ALP) levels have been associated with hypertension, and ALP is known as an enzyme affected by alcohol consumption, no study has been published on the associations between ALP and the risk of hypertension in relation to drinking status.

Methods: We conducted a cross-sectional study of 2,681 participants (837 men and 1,846 women) aged 30 to 89 years undergoing a general health check-up to investigate the associations between ALP and hypertension in relation to drinking status.

Results: Of the 2,681 participants, 1,549 (514 men and 1,035 women) were diagnosed with hypertension. A sex difference was observed for the relationship between ALP and hypertension. While no significant association was observed for men, the association was significantly positive for women. The multivariable adjusted odds ratio and 95% coincidence interval (CI) of hypertension per increment of 1-log ALP were 0.95 (95% CI: 0.56 to 1.59) for men and 1.57 (95% CI: 1.07 to 2.33) for women. When this analysis was restricted to nondrinkers, a significantly elevated risk of hypertension was observed for men and remained significant for women; that is, 3.32 (95% CI: 1.38 to 8.02) for men and 1.68 (95% CI: 1.11 to 2.55) for women.

Conclusion: ALP is associated with hypertension for both male and female nondrinkers, but not for drinkers. For analyses of associations between ALP and blood pressure, alcohol consumption should thus be considered a potential confounder.

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日本农村人口中碱性磷酸酶与高血压之间的关系：长崎群岛研究。

背景：虽然血清碱性磷酸酶（ALP）水平与高血压有关，而且众所周知ALP是一种受饮酒影响的酶，但目前还没有关于ALP和高血压风险与饮酒状况之间关系的研究：我们对 2,681 名年龄在 30 至 89 岁之间、接受一般健康检查的参与者（男性 837 人，女性 1,846 人）进行了横断面研究，以调查 ALP 与高血压之间与饮酒状况的关系：在 2,681 名参与者中，1,549 人（男性 514 人，女性 1,035 人）被诊断为高血压。ALP与高血压之间的关系存在性别差异。男性与高血压的关系不明显，而女性与高血压的关系则明显呈正相关。高血压的多变量调整几率比例和 95% 的巧合区间 (CI)为：男性 ALP 每增加 1 log，其几率比例为 0.95（95% CI：0.56 至 1.59）；女性 ALP 每增加 1 log，其几率比例为 1.57（95% CI：1.07 至 2.33）。当该分析仅限于不饮酒者时，观察到男性患高血压的风险显著升高，而女性患高血压的风险仍显著升高，即男性为 3.32（95% CI：1.38 至 8.02），女性为 1.68（95% CI：1.11 至 2.55）：结论：ALP与男性和女性非饮酒者的高血压有关，但与饮酒者无关。因此，在分析 ALP 与血压之间的关系时，应将饮酒视为潜在的混淆因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physiological Anthropology PHYSIOLOGY-

自引率

6.50%

发文量

期刊介绍： Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment. The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life. Topic areas include, but are not limited to: environmental physiology bio-cultural environment living environment epigenetic adaptation development and growth age and sex differences nutrition and morphology physical fitness and health Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.