Corticosteroid Induced, HHV-8 Positive Kaposi's Sarcoma in a Non-HIV Elderly Patient.

The Journal of IMA Pub Date : 2012-08-15 Print Date: 2012-01-01 DOI:10.5915/44-1-9317
Gh Mohiuddin Wani, Sheikh Manzoor Ahmad, Seema Qayoom, Bilquees Khursheed, A R Khan
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引用次数: 6

Abstract

Kaposi's sarcoma (KS) was first described in 1872 by Moritz Kaposi. In 1994, Chang et al. first identified DNA sequences corresponding to human herpesvirus-8 (HHV-8) in AIDS-associated Kaposi sarcoma biopsies. It is now believed that presence of HHV-8 is necessary but not sufficient to cause KS. Other factors like immunosuppressive therapy also play a role. We describe an HIV-negative elderly patient who developed KS of skin and mucous membrane after prolonged use of corticosteroids for knee pain. The patient was positive for HHV-8.

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皮质类固醇诱导的非hiv老年患者HHV-8阳性卡波西肉瘤
卡波西肉瘤(KS)最早是由莫里茨·卡波西于1872年发现的。1994年,Chang等人首次在艾滋病相关的卡波西肉瘤活检中发现了与人类疱疹病毒-8 (HHV-8)相对应的DNA序列。现在认为,HHV-8的存在是导致KS的必要条件,但不是充分条件。免疫抑制疗法等其他因素也起作用。我们描述了一个hiv阴性的老年患者谁开发皮肤和粘膜KS后,长期使用皮质类固醇治疗膝关节疼痛。该患者HHV-8阳性。
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