Tropospheric formaldehyde levels infer ambient formaldehyde-induced brain diseases and global burden in China, 2013–2019

IF 8.2 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ye Yuan , Yiqing Wu , Hang Zhao , Jie Ren , Wenting Su , Yiduo Kou , Qi Wang , Jianhua Cheng , Zhiqian Tong
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Abstract

Although air pollutions cause human diseases, no epidemiological study has investigated the effect of exposure to air pollutants on brain diseases in the general population. Our objective was to examine the association between tropospheric airborne pollutants and human health risk and global burden, especially, attributable to indoor formaldehyde (FA) pollution in China. The data of tropospheric pollutants, such as: CO, NO, O3, PM2.5 or PM10, SO2, and FA in China, 2013–2019, which were derived from the database of satellite remote-sensing, were first calculated and then analyzed them according to satellite cloud pictures. The rate of prevalence, incidence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) of the Chinese population was obtained from the Global Burden of Diseases (GBD 2010). A linear regression analysis was used to evaluate the relationship between tropospheric FA concentrations and GBD indexes of human brain diseases, the numbers of fire plot, the average summer temperature, population density and car sales in China from 2013 to 2019. Our results showed that the levels of tropospheric FA could reflect the degree of indoor air FA pollution on a nationwide scale in China; in particular, only tropospheric FA exhibited a positive correlation with the rates of both prevalence and YLDs in brain diseases including: Alzheimer's disease (AD) and brain cancer, but not in Parkinson's disease and depression. In particular, the spatial-temporal changes in tropospheric FA levels were consistent with the geographical distribution of FA exposure-induced AD and brain cancer in both sex old adults with age (60–89). In addition, summer average temperature, car sales and population density were positively correlated with tropospheric FA levels in China, 2013–2019. Hence, mapping of tropospheric pollutants could be used for air quality monitoring and health risk assessment.

Abstract Image

2013-2019年中国对流层甲醛水平推断环境甲醛诱发的脑疾病和全球负担
虽然空气污染导致人类疾病,但没有流行病学研究调查接触空气污染物对一般人群脑部疾病的影响。我们的目的是研究对流层空气污染物与人类健康风险和全球负担之间的关系,特别是中国室内甲醛(FA)污染。利用卫星遥感数据库2013-2019年中国对流层CO、NO、O3、PM2.5或PM10、SO2、FA等污染物数据进行计算,并结合卫星云图进行分析。中国人口的患病率、发病率、死亡率、生命损失年数(YLLs)、残疾生活年数(YLDs)和残疾调整生命年(DALYs)的数据来自全球疾病负担(GBD 2010)。采用线性回归分析方法,评价了2013 - 2019年中国对流层FA浓度与人类脑部疾病GBD指数、火灾小区数量、夏季平均气温、人口密度和汽车销量的关系。结果表明:在全国范围内,对流层FA水平可以反映中国室内空气FA污染程度;特别是,只有对流层FA与阿尔茨海默病(AD)和脑癌等脑部疾病的患病率和YLDs呈正相关,而与帕金森病和抑郁症无关。特别是,对流层FA水平的时空变化与FA暴露诱发AD和脑癌的地理分布一致(60-89岁)。此外,2013-2019年中国夏季平均气温、汽车销量和人口密度与对流层FA水平呈正相关。因此,对流层污染物制图可用于空气质量监测和健康风险评估。
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来源期刊
Science of the Total Environment
Science of the Total Environment 环境科学-环境科学
CiteScore
17.60
自引率
10.20%
发文量
8726
审稿时长
2.4 months
期刊介绍: The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.
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