Marine algae sulfated polysaccharides for tissue engineering and drug delivery approaches.

Biomatter Pub Date : 2012-10-01 DOI:10.4161/biom.22947
Tiago H Silva, Anabela Alves, Elena G Popa, Lara L Reys, Manuela E Gomes, Rui A Sousa, Simone S Silva, João F Mano, Rui L Reis
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引用次数: 0

Abstract

Biomedical field is constantly requesting for new biomaterials, with innovative properties. Natural polymers appear as materials of election for this goal due to their biocompatibility and biodegradability. In particular, materials found in marine environment are of great interest since the chemical and biological diversity found in this environment is almost uncountable and continuously growing with the research in deeper waters. Moreover, there is also a slower risk of these materials to pose illnesses to humans.   In particular, sulfated polysaccharides can be found in marine environment, in different algae species. These polysaccharides don't have equivalent in the terrestrial plants and resembles the chemical and biological properties of mammalian glycosaminoglycans. In this perspective, are receiving growing interest for application on health-related fields. On this review, we will focus on the biomedical applications of marine algae sulfated polymers, in particular on the development of innovative systems for tissue engineering and drug delivery approaches.

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Abstract Image

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用于组织工程和药物输送方法的海藻硫酸化多糖。
生物医学领域不断需要具有创新特性的新型生物材料。天然聚合物因其生物相容性和生物可降解性而成为实现这一目标的首选材料。在海洋环境中发现的材料尤其令人感兴趣,因为在这种环境中发现的化学和生物多样性几乎难以计数,而且随着对更深水域的研究,这种多样性还在不断增加。此外,这些材料对人类造成疾病的风险也较低。 特别是,硫酸化多糖可以在海洋环境中的不同藻类中发现。这些多糖在陆生植物中并不存在,其化学和生物特性类似于哺乳动物的糖胺聚糖。因此,这些多糖在健康相关领域的应用正受到越来越多的关注。在本综述中,我们将重点介绍海藻硫酸化聚合物在生物医学方面的应用,特别是组织工程和药物输送方法创新系统的开发。
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