A Bartke, H Brown-Borg, B Kinney, J Mattison, C Wright, S Hauck, K Coschigano, J Kopchick
{"title":"Growth hormone and aging.","authors":"A Bartke, H Brown-Borg, B Kinney, J Mattison, C Wright, S Hauck, K Coschigano, J Kopchick","doi":"10.1007/s11357-000-0021-x","DOIUrl":null,"url":null,"abstract":"<p><p>The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on growth, development, and adult body size may serve as important determinants of aging and life span, while the age-related decline in GH levels contributes to some of the symptoms of aging.</p>","PeriodicalId":89818,"journal":{"name":"Journal of the American Aging Association","volume":"23 4","pages":"219-25"},"PeriodicalIF":0.0000,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-000-0021-x","citationCount":"25","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Aging Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s11357-000-0021-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 25
Abstract
The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on growth, development, and adult body size may serve as important determinants of aging and life span, while the age-related decline in GH levels contributes to some of the symptoms of aging.
生长激素(GH)作为一种抗衰老疗法的潜在用途是目前相当感兴趣的。生长激素的分泌通常会随着年龄的增长而下降，服用生长激素可以逆转与年龄相关的身体成分变化。然而，先天性生长激素缺乏的突变侏儒小鼠和GH- r - ko抗性小鼠比其正常兄弟姐妹活得更长，而病理性生长激素水平升高会降低小鼠和男性的预期寿命。我们提出生长激素对生长、发育和成人体型的作用可能是衰老和寿命的重要决定因素，而与年龄相关的生长激素水平下降有助于衰老的一些症状。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
