Oral Nicotine Self-Administration in Rodents.

Allan C Collins, Sakire Pogun, Tanseli Nesil, Lutfiye Kanit
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引用次数: 29

Abstract

Nicotine addiction is a complex process that begins with self-administration. Consequently, this process has been studied extensively using animal models. A person is usually not called "smoker" if s/he has smoked for a week or a month in a lifetime; in general, a smoker has been smoking for many years. Furthermore, a smoker has free access to cigarettes and can smoke whenever she/he wants, provided there are no social/legal restraints. Subsequently, in an animal model of tobacco addiction, it will be desirable to expose the animal to free access nicotine for 24 hours/day for many weeks, starting at different stages of development.

啮齿动物口服尼古丁自我给药。
尼古丁成瘾是一个复杂的过程,从自我服用开始。因此,这一过程已经在动物模型上进行了广泛的研究。如果一个人一生中吸烟一周或一个月,通常不会被称为“吸烟者”;一般来说,吸烟者已经吸烟很多年了。此外,吸烟者可以自由获取香烟,只要不受社会/法律限制,他/她可以随时吸烟。随后,在烟草成瘾的动物模型中,从不同的发育阶段开始,让动物每天24小时免费接触尼古丁,持续数周是可取的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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