Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-08-07 DOI:10.1155/2012/504693
Yen-Hsien Lee, Jung-Jhih Chang, Chiang-Ting Chien, Ming-Chien Yang, Hsiung-Fei Chien
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引用次数: 51

Abstract

We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel). The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined. In vitro data showed that after 6 hours of air exposure, the order of the scavenging abilities for HOCl, H(2)O(2), and O(2) (-) was antioxidant sol-gel > antioxidant saline > Pluronic F127 = saline. After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation. However, the wounds of all treatments healed mostly at 3 weeks. Vitamin C in Pluronic F127 hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system. This study showed that Pluronic F127 plus vitamin C could potentially be employed as a novel wound-healing enhancer.

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抗氧化剂溶胶-凝胶促进链脲佐菌素诱导的糖尿病大鼠皮肤伤口愈合。
我们检测了Pluronic F127中维生素C对糖尿病伤口愈合的影响。采用生理盐水、生理盐水加维生素C(抗氧化溶胶)、Pluronic F127、Pluronic F127加维生素C(抗氧化溶胶-凝胶)对正常和糖尿病Wistar大鼠皮肤全层切除创面的影响进行评价。观察创面收缩速度、表皮和真皮成熟水平、胶原合成水平和创面组织细胞凋亡水平。体外数据显示,暴露于空气6 H后,对HOCl、H(2)O(2)和O(2)(-)的清除能力依次为抗氧化溶胶-凝胶>抗氧化生理盐水> Pluronic F127 =生理盐水。在创面损伤7天和14天后,抗氧化溶胶-凝胶通过加速表皮和真皮成熟、增加胶原含量和减少细胞凋亡的形成,显著促进创面愈合。然而,所有治疗方法的伤口愈合大多在3周。Pluronic F127中的维生素C通过良好的给药系统,通过其抗氧化和抗凋亡机制加速皮肤伤口愈合。本研究表明Pluronic F127加维生素C可能作为一种新型的伤口愈合促进剂。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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3-8 weeks
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