Maternal exposure to metal mixtures during early pregnancy and fetal growth in the Jiangsu Birth Cohort, China

IF 4.4 2区化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Polymer Materials Pub Date : 2022-12-01 DOI:10.1016/j.envres.2022.114305

Yuanyan Dou , Yin Yin , Zhi Li , Jiangbo Du , Yangqian Jiang , Tao Jiang , Wenhui Guo , Rui Qin , Mei Li , Hong Lv , Qun Lu , Yun Qiu , Yuan Lin , Guangfu Jin , Chuncheng Lu , Hongxia Ma , Zhibin Hu , China National Birth Cohort (CNBC Study Group)

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引用次数: 7

Abstract

Previous epidemiological studies have reported that prenatal exposure to metals might have influence on fetal growth. Most studies assessed the effect of individual metals, while the investigation on the relationship between multiple metal exposure and fetal growth is sparse. The objective of the present study is to assess the joint impact of metal mixtures on fetal growth during pregnancy. A total of 1275 maternal-infant pairs from the Jiangsu Birth Cohort (JBC) Study were included to investigate the effect of maternal metal exposure on fetal biometry measures at 22–24, 30–32, and 34–36 weeks of gestation. Lead (Pb), arsenic (As), cadmium (Cd), mercury (Hg), chromium (Cr), vanadium(V), thallium (Tl) and barium (Ba) were measured by inductively coupled plasma mass spectrometry (ICP-MS) in maternal urine samples collected in the first trimester. We used general linear models and restricted cubic splines to test dose-response relationships between single metals and fetal growth. The weighted quantile sum (WQS) models were then applied to evaluate the overall effect of all these metals. We observed inverse associations of exposure to Pb, V and Cr with estimated fetal weight (EFW) at 34–36 weeks of gestation. Notably, maternal exposure to metal mixtures was significantly associated with reduced EFW at 34–36 weeks of gestation after adjusting for some covariates and confounders (aβ −0.05 [95% CI: 0.09, −0.01], P = 0.023), and this association was mainly driven by Cr (30.41%), Pb (23.92%), and Tl (15.60%). These findings indicated that prenatal exposure to metal mixtures might impose adverse effects on fetal growth.

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中国江苏出生队列孕妇在妊娠早期接触金属混合物与胎儿生长的关系

以前的流行病学研究报告说，产前接触金属可能对胎儿生长有影响。大多数研究评估了单个金属的影响，而对多种金属暴露与胎儿生长之间关系的调查很少。本研究的目的是评估金属混合物对妊娠期间胎儿生长的联合影响。研究对象为1275对来自江苏出生队列(JBC)研究的母婴，研究母体金属暴露对妊娠22-24周、30-32周和34-36周胎儿生物测量的影响。采用电感耦合等离子体质谱法(ICP-MS)测定孕早期产妇尿液中的铅(Pb)、砷(As)、镉(Cd)、汞(Hg)、铬(Cr)、钒(V)、铊(Tl)和钡(Ba)含量。我们使用一般线性模型和限制三次样条来测试单一金属与胎儿生长之间的剂量-反应关系。然后应用加权分位数和(WQS)模型来评估所有这些金属的总体影响。我们观察到在妊娠34-36周时，暴露于铅、V和Cr与胎儿体重(EFW)呈负相关。值得注意的是，在调整了一些协变量和混杂因素后，母体接触金属混合物与妊娠34-36周EFW的降低显著相关(aβ−0.05 [95% CI: 0.09，−0.01]，P = 0.023)，这种关联主要由Cr(30.41%)、Pb(23.92%)和Tl(15.60%)驱动。这些发现表明，产前接触金属混合物可能对胎儿生长产生不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Polymer Materials Multiple-

CiteScore

7.20

自引率

6.00%

发文量

810

期刊介绍： ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.