Recent experimental advances in probing the colloidal properties of viruses

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science Pub Date : 2023-08-01 DOI:10.1016/j.cocis.2023.101703

Antonius Armanious , Milad Radiom , Raffaele Mezzenga

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引用次数: 1

Abstract

Colloidal properties of viruses largely define the stability, transport, and host interactions of viruses. Despite attempts to unravel the correlation between colloidal virus properties and their interactions outside and inside their host, an in-depth understanding is still missing. This knowledge gap is, to a great extent, caused by challenges associated with the capacity to probe these properties experimentally; thus, great efforts are being invested in developing new approaches or transforming existing ones to characterize the physical-chemical, i.e., colloidal, properties of viruses. Understanding the correlation between these properties and virus interactions is not only important from a scientific point of view but will also hopefully inspire the design of novel viral vectors and virus-like particles for biomedical applications. In this review, we cover the recent experimental advances in characterizing the colloidal properties of viruses with particular attention to virus hydrophobicity, genetic load, nanomechanical properties, and surface interaction forces with host cells.

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探测病毒胶体特性的最新实验进展

病毒的胶体特性在很大程度上决定了病毒的稳定性、运输和与宿主的相互作用。尽管人们试图揭示胶体病毒特性与它们在宿主内外的相互作用之间的相关性，但仍缺乏深入的了解。这种知识差距在很大程度上是由与实验探测这些特性的能力相关的挑战引起的;因此，人们正在大力发展新方法或改造现有方法，以表征病毒的物理化学特性，即胶体特性。了解这些特性与病毒相互作用之间的相关性不仅从科学的角度来看很重要，而且有望启发设计用于生物医学应用的新型病毒载体和病毒样颗粒。在这篇综述中，我们介绍了最近在表征病毒胶体特性方面的实验进展，特别关注病毒的疏水性、遗传负荷、纳米力学特性以及与宿主细胞的表面相互作用力。

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来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.