Expression of MUC1 (Ma695) in noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification of the noninvasive urothelial neoplasm. An immunologic tool for the pathologist?

Analytical and quantitative cytology and histology Pub Date : 2011-10-01

Christian Garbar, Corinne Mascaux

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Abstract

Objective: To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification.

Study design: Histologic evaluation was performed in 46 patients with nontumoral benign bladder urothelium (n = 11), papillary urothelial neoplasm of low malignant potential (PUNLMP) (n = 14), low-grade papillary urothelial carcinoma (LgPUC) (n = 11), and noninvasive high-grade papillary urothelial carcinoma (HgPUC) (n = 10). Classical morphologic description and semiquantitative digital measurement were performed from immunohistochemical-stained slides using an anti-MUC1 antibody (Ma695).

Results: Measures showed an obvious statistical difference between benign urothelium and LgPUC (p = 0.0004) or HgPUC (p = 0.0041). MUC1 is expressed less in PUNLMP than in LgPUC (p = 0.04). Benign urothelium and PUNLMP more often showed apical and superficial MUC1 expression. Basal cells with cytoplasmic and/or circumferential membrane positivity were more often observed in LgPUC and HgPUC (p < 0.001).

Conclusion: MUC1 could be an interesting tool for the pathologist to differentiate between PUNLMP and LgPUC or HgPUC.

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根据2004年世界卫生组织对非侵袭性尿路上皮肿瘤的分类MUC1 (Ma695)在非侵袭性乳头状尿路上皮肿瘤中的表达。病理学家的免疫工具?

目的:根据2004年世界卫生组织分类，探讨MUC1 (Ma695)与非侵袭性乳头状尿路上皮肿瘤的关系。研究设计:对46例非肿瘤性良性膀胱尿路上皮(n = 11)、低恶性潜能乳头状尿路上皮肿瘤(n = 14)、低级别乳头状尿路上皮癌(n = 11)和非侵袭性高级别乳头状尿路上皮癌(n = 10)进行组织学评估。使用抗muc1抗体(Ma695)对免疫组织化学染色的载玻片进行经典形态学描述和半定量数字测量。结果:测量结果显示良性尿路上皮与LgPUC (p = 0.0004)、HgPUC (p = 0.0041)差异有统计学意义。MUC1在PUNLMP中的表达量低于LgPUC (p = 0.04)。良性尿路上皮和PUNLMP多表现为顶端和浅表MUC1表达。基底细胞细胞质和/或周膜阳性在LgPUC和HgPUC中更为常见(p < 0.001)。结论:MUC1可能是病理学家鉴别PUNLMP与LgPUC或HgPUC的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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