Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia.

Analytical and quantitative cytology and histology Pub Date : 2011-10-01

Vladimir Kirillov, Olga Emeliyanova

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Abstract

Objective: To determine the efficiency of the developed expert system based on a set of qualitative signs of cell atypia and their weighting coefficients in the differential diagnosis of follicular cancer and follicular adenoma of the thyroid gland.

Study design: Sixty cytologic preparations of patients with histologic diagnosis of a follicular cancer and follicular adenoma were investigated.

Results: Weighting coefficients for each sign of atypia for both forms of pathology have been calculated with the help of the deduced equation. This allowed creating an expert system by which the function of transforming qualitative signs of cell atypia to a quantitative form was realized. "Strength reserve" according to the diagnostic index value, coincidence of the verified diagnosis with the histologic conclusion, and its invariability for all 12 iterations testified to the reliability of an expert system. Preliminary trials showed the efficiency of an expert system for differentiating the nature of a thyroid follicular tumor to be 97.5%.

Conclusion: The developed expert system allows high efficiency in making a differential diagnosis of thyroid follicular cancer and follicular adenoma.

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基于一组细胞异型性定性标志的专家系统对滤泡癌和滤泡腺瘤的鉴别诊断。

目的:探讨基于细胞异型性定性标志及其加权系数的专家系统在甲状腺滤泡癌和滤泡腺瘤鉴别诊断中的效率。研究设计:对60例组织学诊断为滤泡癌和滤泡腺瘤的患者进行细胞学检查。结果:在推导出的方程的帮助下，计算了两种病理形式的非典型性的每个征象的加权系数。这允许创建一个专家系统，通过该系统实现了将细胞异型性的定性标志转化为定量形式的功能。根据诊断指标值的“强度储备”，验证诊断与组织学结论的符合性，以及12次迭代的不变性，证明了专家系统的可靠性。初步试验表明，专家系统鉴别甲状腺滤泡性肿瘤性质的效率为97.5%。结论:所开发的专家系统对甲状腺滤泡癌和滤泡腺瘤的鉴别诊断具有较高的效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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