Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis.

Analytical and quantitative cytology and histology Pub Date : 2012-02-01

Mohamed Ali Bedaiwy, Javier Noriega, Mahmoud Abdel Aleem, Sajal Gupta, Ahmed M AbulHassan, Jennifer Brainard, Alaa M Ismail, Tommaso Falcone

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Abstract

Objective: To evaluate peritoneal fluid hemosiderin-laden macrophages (H-LMs) in patients with endometriosis compared to controls.

Study design: Consecutive series of 46 patients during a year undergoing laparoscopy for benign gynecologic conditions were included. The presence of H-LMs in peritoneal fluid was evaluated. We compared clinical factors in patients with or without endometriosis in respect to H-LM status. To assess the potential of H-LMs to diagnose endometriosis, the sensitivity and specificity were calculated.

Results: Patients with endometriosis were significantly more likely to have positive H-LM test results than controls (p = 0.0013). The presence of H-LM has a low sensitivity of 52% but an acceptable specificity of 87% in diagnosing endometriosis. The presence of H-LMs was not related with any other of the clinical factors studied.

Conclusion: The presence of specific findings of H-LMs related to endometriosis strongly suggests abnormalities in peritoneal iron metabolism.

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活检证实的子宫内膜异位症腹膜液含铁血黄素巨噬细胞的评价。

目的:评价子宫内膜异位症患者腹膜液含铁血黄素巨噬细胞(H-LMs)与对照组的差异。研究设计:连续纳入46例一年内因良性妇科疾病接受腹腔镜检查的患者。评估腹膜液中h - lm的存在。我们比较了有或没有子宫内膜异位症患者的H-LM状态的临床因素。为了评估H-LMs诊断子宫内膜异位症的潜力，我们计算了其敏感性和特异性。结果:子宫内膜异位症患者H-LM检测阳性的可能性明显高于对照组(p = 0.0013)。H-LM诊断子宫内膜异位症的敏感性较低，为52%，但可接受的特异性为87%。H-LMs的存在与所研究的任何其他临床因素无关。结论:与子宫内膜异位症相关的H-LMs的特异性表现强烈提示腹膜铁代谢异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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