Molecular findings of nasopharyngeal carcinoma in a European population.

Analytical and quantitative cytology and histology Pub Date : 2011-12-01

María Teresa González Serrano, María José Ríos Moreno, Manuel de Miguel Rodríguez, Fernando Casco, Hugo Galera-Ruiz, María Teresa Vargas de los Monteros, Inmaculada Trigo Sánchez, Ricardo González-Cámpora, Hugo Galera-Davidson

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Abstract

Objective: To explore biomolecular characteristics of a group of patients with nasopharyngeal carcinoma from European (Spanish) hospitals, addressing the pathogenesis of the tumor and the response to treatment.

Study design: Cyclin D1 and p16 expression were evaluated immunohistochemically in 33 tissue samples of nasopharyngeal carcinoma. CCDN1 gene amplification and p16 gene deletion were studied by fluorescence in situ hybridization. Patient clinical data were examined, and tissues were evaluated histologically using hematoxylin-eosin staining.

Results: Cyclin D1 overexpression was found in 19 cases, and p16 expression was undetected in 30 cases. An association was observed between impaired p16 expression and cyclin D1 overexpression (p = 0.034). Eleven patients displayed p16 gene deletion and CCDN1 gene amplification.

Conclusion: Cyclin D1 overexpression and CCDN1 amplification, loss of p16 expression and p16 deletion may be among the genetic alterations involved in the pathogenesis of nasopharyngeal carcinoma.

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欧洲人群鼻咽癌的分子研究结果。

目的:探讨来自欧洲(西班牙)医院的一组鼻咽癌患者的生物分子特征，探讨肿瘤的发病机制和治疗反应。研究设计:用免疫组织化学方法评价33例鼻咽癌组织样本中Cyclin D1和p16的表达。采用荧光原位杂交技术对CCDN1基因扩增和p16基因缺失进行了研究。检查患者临床资料，并用苏木精-伊红染色对组织进行组织学评估。结果:Cyclin D1过表达19例，p16未表达30例。p16表达受损与cyclin D1过表达之间存在相关性(p = 0.034)。11例患者出现p16基因缺失和CCDN1基因扩增。结论:cyclind1过表达、CCDN1扩增、p16表达缺失和p16缺失可能是鼻咽癌发生的基因改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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