Sex differences in the association between level of childhood interleukin-6 and insulin resistance in adolescence.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-01-05 DOI:10.1155/2012/859186

Anna Bugge, Bianca El-Naaman, Robert G McMurray, Karsten Froberg, Claus Henrik Nielsen, Klaus Müller, Lars Bo Andersen

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引用次数: 7

Abstract

The purpose of this study was to determine whether levels of interleukin-6 (IL-6) in childhood are related to insulin resistance in adolescence. Further, to explore how fatness and cardiorespiratory fitness (VO(2peak)) moderate this relationship. Methods. 292 nine-year-old children (n = 292) were followed for 4 years. Anthropometrics and VO(2peak) were measured. Fasting blood samples were analyzed for IL-6, insulin, and glucose. Homeostasis model assessment (HOMA-IR) was used as a measure of insulin resistance. Results. For girls but not boys, levels of IL-6 at age 9 yrs correlated with HOMA-IR at age 13 yrs: r = 0.223, P = 0.008. Girls with IL-6 levels within the highest quartile at age 9 yrs had an odds ratio of 3.68 (CI = 1.58-8.57) being in the highest quartile of HOMA-IR four years later. Conclusion. In this cohort, IL-6 levels in childhood were related to insulin resistance in adolescence, but only for girls.

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儿童白细胞介素-6水平与青春期胰岛素抵抗之间的性别差异。

本研究的目的是确定儿童时期的白细胞介素-6 (IL-6)水平是否与青春期的胰岛素抵抗有关。进一步，探讨肥胖和心肺健康(VO(2peak))如何调节这种关系。方法:对292名9岁儿童(n = 292)进行为期4年的随访。测量人体测量和VO(2peak)。空腹血液样本分析IL-6、胰岛素和葡萄糖。体内平衡模型评估(HOMA-IR)被用来衡量胰岛素抵抗。结果。女孩9岁时IL-6水平与男孩13岁时HOMA-IR相关:r = 0.223, P = 0.008。在9岁时IL-6水平处于最高四分位数的女孩在4年后HOMA-IR处于最高四分位数的优势比为3.68 (CI = 1.58-8.57)。结论。在这个队列中，儿童时期的IL-6水平与青春期的胰岛素抵抗有关，但仅适用于女孩。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Diabetes Research 医学-内分泌学与代谢

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审稿时长

3-8 weeks