E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis.

Q2 Biochemistry, Genetics and Molecular Biology

Cell Communication and Adhesion Pub Date : 2011-12-01 Epub Date: 2011-12-19 DOI:10.3109/15419061.2011.636465

Andrea Buda, Massimo Pignatelli

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引用次数: 62

Abstract

Abnormalities in the expression and functional activity of cell adhesion molecules are implicated in the development and progression of the majority of colorectal cancers (CRC). Cell-cell adhesion molecule E-cadherin regulates cell polarity, differentiation, proliferation and migration through its intimate association to the actin cytoskeletal network. During colorectal carcinogenesis changes in intercellular adhesion and dynamic rearrangements in the actin cytoskeleton result in altered signalling and migration with loss of contact inhibition. The adenomatous polyposis coli (APC) protein, besides its established role in the β catenin/Wnt signalling pathway, can coordinate microtubule and actin organization during cell migration. The actin-bundling protein Fascin promotes cell motility and is overexpressed in CRC. Based on recent molecular and pathological studies, this review focusses on the role of these molecules sharing the common feature of being associated with the cytoskeletal network during colorectal carcinogenesis and metastasis. The potential use of these molecules as prognostic markers and/or therapeutic targets will also be discussed.

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e -钙粘蛋白和细胞骨架网络在结直肠癌发展和转移中的作用。

细胞粘附分子的表达和功能活性异常与大多数结直肠癌(CRC)的发生和进展有关。细胞粘附分子E-cadherin通过与肌动蛋白细胞骨架网络的密切联系调节细胞极性、分化、增殖和迁移。在结直肠癌发生过程中，细胞间粘附的变化和肌动蛋白细胞骨架的动态重排导致信号传导和迁移的改变，并失去接触抑制。大肠腺瘤性息肉病(APC)蛋白除了在β catenin/Wnt信号通路中发挥既定作用外，还可以在细胞迁移过程中协调微管和肌动蛋白的组织。肌动蛋白结合蛋白fasin促进细胞运动，在结直肠癌中过度表达。基于最近的分子和病理研究，本文综述了这些分子在结直肠癌发生和转移过程中的作用，这些分子具有与细胞骨架网络相关的共同特征。这些分子作为预后标记物和/或治疗靶点的潜在用途也将被讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Adhesion 生物-生化与分子生物学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation Cell Communication and Adhesion is an international Open Access journal which provides a central forum for research on mechanisms underlying cellular signalling and adhesion. The journal provides a single source of information concerning all forms of cellular communication, cell junctions, adhesion molecules and families of receptors from diverse biological systems. The journal welcomes submission of original research articles, reviews, short communications and conference reports.