Titanium Dioxide Nanoparticles in sunscreens and skin photo-damage. Development, synthesis and characterization of a novel biocompatible alternative based on their in vitro and in vivo study

IF 3.261
M.Virginia Vaudagna , Virginia Aiassa , Aida Marcotti , María Fernanda Pince Beti , María Florencia Constantín , Mariela Fernanda Pérez , Ariana Zoppi , María Cecilia Becerra , M.Jazmin Silvero C․
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引用次数: 0

Abstract

Titanium dioxide nanoparticles are widely used in cosmetics, especially in sunscreens due to their capacity to absorb UV harmful wavelengths. However, their biocompatibility remains controversial. In this work, the effect of titanium dioxide nanoparticles, particularly Degussa P25 (P25TiO2NPs) under solar-simulated radiation was studied in vitro and in vivo. Cell viability and tissue integrity were affected after exposure to P25TiO2NPs and light for 6 h, showing signs of significant oxidative stress markers and reduced tissue integrity observed by TEM. In order to avoid these undesired effects, a novel biocompatible alternative was presented based on titanium dioxide nanoparticle functionalization with vitamin B2 through a rapid sol-gel method. None of the phototoxicity effects were observed with these functionalized nanoparticles.

Abstract Image

防晒霜中的二氧化钛纳米粒子和光损伤皮肤。基于体外和体内研究的新型生物相容性替代品的开发、合成和表征
二氧化钛纳米粒子被广泛应用于化妆品,特别是防晒霜,因为它们能够吸收紫外线的有害波长。然而,它们的生物相容性仍然存在争议。本研究在体外和体内研究了二氧化钛纳米粒子,特别是德固赛P25 (P25TiO2NPs)在太阳模拟辐射下的作用。在P25TiO2NPs和光照下暴露6小时后,细胞活力和组织完整性受到影响,透射电镜观察到明显的氧化应激标志物和组织完整性降低。为了避免这些不良影响,通过快速溶胶-凝胶方法,提出了一种基于二氧化钛纳米颗粒与维生素B2功能化的新型生物相容性替代品。这些功能化纳米颗粒未观察到光毒性作用。
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CiteScore
4.10
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