David-Olivier D Azulay, Benjamin Renoux, Magnus Ivarsson
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引用次数: 1
Abstract
Background: Changes caused by clonidine in rodent electroencephalograms (EEG) have been reported with some inconsistency. For this reason, a pre-clinical study was conducted in order to confirm previous findings with both a standard spectral analysis and a sleep stage scoring procedure. In addition, a nonlinear technique for analysing the time-varying signals was implemented to compare its performance against conventional approaches.
Results: The nonlinear method succeeds in quantifying all dose-related responses from the data set relying solely on the EEG trace.
Conclusions: Nonlinear approaches can deliver a suitable alternative to the sleep-stage scoring methods commonly used for drug effect detection.
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