Treatment of infection and inflammation associated with COVID-19, multi-drug resistant pneumonia and fungal sinusitis by nebulizing a nanosilver solution

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-02-01 DOI:10.1016/j.nano.2023.102654

Patricia L. Nadworny PhD , William L. Hickerson MD , Holly Denise Holley-Harrison MSN/NP , David C. Bloom PhD , Tristan R. Grams BS , Terri G. Edwards BS , Gregory S. Schultz PhD , Robert E. Burrell PhD

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引用次数: 3

Abstract

Solutions containing Ag⁰ nanoclusters, Ag⁺¹, and higher oxidation state silver, generated from nanocrystalline silver dressings, were anti-inflammatory against porcine skin inflammation. The dressings have clinically-demonstrated broad-spectrum antimicrobial activity, suggesting application of nanosilver solutions in treating pulmonary infection.

Nanosilver solutions were tested for antimicrobial efficacy; against HSV-1 and SARS-CoV-2; and nebulized in rats with acute pneumonia. Patients with pneumonia (ventilated), fungal sinusitis, burns plus COVID-19, and two non-hospitalized patients with COVID-19 received nebulized nanosilver solution.

Nanosilver solutions demonstrated pH-dependent antimicrobial efficacy; reduced infection and inflammation without evidence of lung toxicity in the rat model; and inactivated HSV-1 and SARS-CoV-2. Pneumonia patients had rapidly reduced pulmonary symptoms, recovering pre-illness respiratory function. Fungal sinusitis-related inflammation decreased immediately with infection clearance within 21 days. Non-hospitalized patients with COVID-19 experienced rapid symptom remission.

Nanosilver solutions, due to anti-inflammatory, antiviral, and antimicrobial activity, may be effective for treating respiratory inflammation and infections caused by viruses and/or microbes.

Abstract Image

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雾化纳米银溶液治疗COVID-19相关感染和炎症、耐多药肺炎和真菌性鼻窦炎

含有Ag0纳米团簇、Ag+1和高氧化态银(由纳米晶银敷料产生)的溶液对猪皮肤炎症具有抗炎作用。该敷料具有临床证明的广谱抗菌活性，提示纳米银溶液在治疗肺部感染中的应用。测试纳米银溶液的抗菌效果;抗HSV-1和SARS-CoV-2;并在急性肺炎大鼠中雾化。肺炎(通气)、真菌性鼻窦炎、烧伤合并COVID-19患者和2例未住院的COVID-19患者接受雾化纳米银溶液。纳米银溶液显示出ph依赖的抗菌效果;在大鼠模型中减少感染和炎症，无肺毒性证据;灭活的HSV-1和SARS-CoV-2。肺炎患者肺部症状迅速减轻，恢复病前呼吸功能。真菌性鼻窦炎相关炎症在21天内感染清除后立即减少。未住院的COVID-19患者症状缓解迅速。纳米银溶液由于具有抗炎、抗病毒和抗菌活性，可有效治疗由病毒和/或微生物引起的呼吸道炎症和感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.