Regulation of RAGE for attenuating progression of diabetic vascular complications.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2011-10-29 DOI:10.1155/2012/894605
Myat Thu Thu Win, Yasuhiko Yamamoto, Seiichi Munesue, Hidehito Saito, Dong Han, So Motoyoshi, Tarek Kamal, Takuro Ohara, Takuo Watanabe, Hiroshi Yamamoto
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引用次数: 53

Abstract

Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has been demonstrated in animal studies. Preventive and therapeutic strategies focusing on RAGE and its ligand axis may be of great importance in relieving diabetic vascular complications and reducing the burden of disease.

Abstract Image

RAGE对糖尿病血管并发症进展的调节。
糖尿病血管病变包括微血管病变和大血管病变,是长期糖尿病患者的高发病率和高死亡率。晚期糖基化终产物受体(RAGE)及其配体被认为是糖尿病血管损伤进展的重要致病诱因。RAGE与糖尿病血管病变之间的有害联系已在动物研究中得到证实。以RAGE及其配体轴为中心的预防和治疗策略可能对减轻糖尿病血管并发症和减轻疾病负担具有重要意义。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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3-8 weeks
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