Min Zhang, Hai-Ming Zhao, Zhen-Ying Qin, Rui Qin, Xiao-Hui Chen, Ya-Ping Zhao, Chun-Mei Zhang, Chun-Lin Gao, Chun Zhu, Chen-Bo Ji, Xin-Guo Cao, Xi-Rong Guo
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引用次数: 5
Abstract
LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.
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