Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2011-10-26 DOI:10.1155/2012/820989
Min Zhang, Hai-Ming Zhao, Zhen-Ying Qin, Rui Qin, Xiao-Hui Chen, Ya-Ping Zhao, Chun-Mei Zhang, Chun-Lin Gao, Chun Zhu, Chen-Bo Ji, Xin-Guo Cao, Xi-Rong Guo
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引用次数: 5

Abstract

LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.

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游离脂肪酸、脂肪因子和罗格列酮对3T3-L1脂肪细胞LYRM1基因表达的调控
LYR motif containing 1 (LYRM1)是一个在肥胖人群脂肪组织中大量表达并参与胰岛素抵抗的新基因。本研究发现,游离脂肪酸(FFAs)和肿瘤坏死因子-α (TNF-α)可上调3T3-L1脂肪细胞中LYRM1 mRNA的表达。相反,抵抗素和罗格列酮对LYRM1 mRNA表达有抑制作用。这些结果表明,LYRM1 mRNA的表达受到多种与胰岛素敏感性相关的因素的影响。LYRM1可能是肥胖相关胰岛素抵抗发展的重要媒介。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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3-8 weeks
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