Five-year progression-free survival in 577 patients operated on with laparoscopic radical prostatectomy for localized prostate cancer.

Scandinavian Journal of Urology and Nephrology Pub Date : 2012-02-01 Epub Date: 2011-08-15 DOI:10.3109/00365599.2011.604790

Viktor Berge, Rolf Eigil Berg, Jon Roar Hoff, Nicolai Wessel, Aud Svindland, Steinar Johan Karlsen, Lars Magne Eri

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引用次数: 8

Abstract

Objective: Laparoscopic radical prostatectomy (LRP) was introduced in the Department of Urology, Oslo University Hospital, in 2002. The aim of this study was to report mid-term oncology results and survival data.

Material and methods: From February 2002 to November 2007, 582 consecutive patients with localized prostate cancer underwent LRP. Data were collected prospectively into a database.

Results: Mean and median follow-up after LRP was 30.3 months (± 15.5) and 36.0 months (range 3-72). Five patients (1%) were lost during follow-up. Two patients died of prostate cancer during the study period and 10 patients died of other causes. The overall positive surgical margin (PSM) rate was 29% and decreased to 13% for the last 100 patients. The overall PSA progression-free survival (PFS) was 85% at 3 years and 73% at 5 years. Gleason score in the tumour specimen, pT stage and surgical margins were statistical significant independent predictors of biochemical PFS.

Conclusion: These oncology results and 5-year PFS data after LRP are in line with other reports.

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577例腹腔镜根治性前列腺切除术治疗局限性前列腺癌患者的5年无进展生存率

目的:2002年在奥斯陆大学医院泌尿外科引进腹腔镜根治性前列腺切除术(LRP)。本研究的目的是报告中期肿瘤学结果和生存数据。材料与方法:2002年2月至2007年11月，582例连续的局限性前列腺癌患者行LRP。前瞻性地将数据收集到数据库中。结果:LRP术后平均随访时间30.3个月(±15.5)，中位随访时间36.0个月(范围3-72)。随访期间丢失5例(1%)。在研究期间，2名患者死于前列腺癌，10名患者死于其他原因。总体阳性手术切缘(PSM)率为29%，在最后100例患者中下降到13%。总体PSA无进展生存期(PFS) 3年为85%，5年为73%。肿瘤标本的Gleason评分、pT分期和手术切缘是生化PFS有统计学意义的独立预测因子。结论:这些肿瘤学结果和LRP后5年PFS数据与其他报道一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Urology and Nephrology 医学-泌尿学与肾脏学

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0.00%

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审稿时长

3 months