{"title":"Control of mRNA stability by SAPKs.","authors":"Miguel A Rodríguez-Gabriel, Paul Russell","doi":"10.1007/4735_2007_0248","DOIUrl":null,"url":null,"abstract":"<p><p>Control of mRNA turnover is an essential step in the regulation of gene expression in eukaryotes. The concerted action of many enzymes regulates the way each mRNA is degraded. Moreover, the degradation of each mRNA is influenced by the environment surrounding the cell. The conection between the environment and changes in the half-lifes of mRNAs is regulated by the activity of stress activated MAP kinases (SAPKs) and their substrates. Here we will describe some of those mechanisms, and how SAPKs regulate mRNA stability in eukaryotic cells.</p>","PeriodicalId":89510,"journal":{"name":"Topics in current genetics","volume":"20 ","pages":"159-170"},"PeriodicalIF":0.0000,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/4735_2007_0248","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Topics in current genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/4735_2007_0248","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Control of mRNA turnover is an essential step in the regulation of gene expression in eukaryotes. The concerted action of many enzymes regulates the way each mRNA is degraded. Moreover, the degradation of each mRNA is influenced by the environment surrounding the cell. The conection between the environment and changes in the half-lifes of mRNAs is regulated by the activity of stress activated MAP kinases (SAPKs) and their substrates. Here we will describe some of those mechanisms, and how SAPKs regulate mRNA stability in eukaryotic cells.
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