Estimating gestational age at birth: a population-based derivation-validation study.

Chronic Diseases and Injuries in Canada Pub Date : 2011-06-01

M L Urquia, T A Stukel, K Fung, R H Glazier, J G Ray

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Abstract

Introduction: Information on newborn gestational age (GA) is essential in research on perinatal and infant health, but it is not always available from administrative databases. We developed and validated a GA prediction model for singleton births for use in epidemiological studies.

Methods: Derivation of estimated GA was calculated based on 130 328 newborn infants born in Ontario hospitals between 2007 and 2009, using linear regression analysis, with several infant and maternal characteristics as the predictor (independent) variables. The model was validated in a separate sample of 130 329 newborns.

Results: The discriminative ability of the linear model based on infant birth weight and sex was reasonably approximate for infants born before the 37th week of gestation (r2 = 0.67; 95% CI: 0.65-0.68), but not for term births (37-42 weeks; r2 = 0.12; 95% CI: 0.12-0.13). Adding other infant and maternal characteristics did not improve the model discrimination.

Conclusion: Newborn gestational age before 37 weeks can be reasonably approximated using locally available data on birth weight and sex.

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估计出生胎龄:一项基于人群的衍生验证研究。

新生儿胎龄(GA)信息在围产期和婴儿健康研究中是必不可少的，但并不总是可以从行政数据库中获得。我们开发并验证了用于流行病学研究的单胎出生遗传预测模型。方法:以2007 - 2009年在安大略省医院出生的130 328名新生儿为研究对象，以婴儿和母亲的几个特征作为预测变量(自变量)，采用线性回归分析计算估计GA的推导。该模型在130 329名新生儿的单独样本中得到验证。结果:基于出生体重和性别的线性模型对妊娠37周前出生的婴儿的判别能力比较接近(r2 = 0.67;95% CI: 0.65-0.68)，但足月分娩(37-42周;R2 = 0.12;95% ci: 0.12-0.13)。添加其他婴儿和母亲的特征并没有改善模型辨别。结论:新生儿37周前的胎龄可以通过当地现有的出生体重和性别数据合理估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronic Diseases and Injuries in Canada PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

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