CD28 co-signaling in the adaptive immune response.

Self/nonself Pub Date : 2010-07-01 Epub Date: 2010-07-12 DOI:10.4161/self.1.3.12968
Pavel Riha, Christopher E Rudd
{"title":"CD28 co-signaling in the adaptive immune response.","authors":"Pavel Riha,&nbsp;Christopher E Rudd","doi":"10.4161/self.1.3.12968","DOIUrl":null,"url":null,"abstract":"<p><p>T-cell proliferation and function depends on signals from the antigen-receptor complex (TCR/CD3) and by various co-receptors such as CD28 and CTLA-4. The balance of positive and negative signals determines the outcome of the T-cell response to foreign and self-antigen. CD28 is a prominent co-receptor in naïve and memory T-cell responses. Its blockade has been exploited clinically to dampen T-cell responses to self-antigen. Current evidence shows that CD28 both potentiates TCR signaling and engages a unique array of mediators (PI3K, Grb2, FLNa) in the regulation of aspects of T-cell signaling including the transcription factor NFkB. In this mini-review, we provide an up-to-date overview of our understanding of the signaling mechanisms that underlie CD28 function and its potential application to the modulation of reactivity to autoimmunity.</p>","PeriodicalId":89270,"journal":{"name":"Self/nonself","volume":"1 3","pages":"231-240"},"PeriodicalIF":0.0000,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/self.1.3.12968","citationCount":"79","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Self/nonself","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4161/self.1.3.12968","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2010/7/12 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 79

Abstract

T-cell proliferation and function depends on signals from the antigen-receptor complex (TCR/CD3) and by various co-receptors such as CD28 and CTLA-4. The balance of positive and negative signals determines the outcome of the T-cell response to foreign and self-antigen. CD28 is a prominent co-receptor in naïve and memory T-cell responses. Its blockade has been exploited clinically to dampen T-cell responses to self-antigen. Current evidence shows that CD28 both potentiates TCR signaling and engages a unique array of mediators (PI3K, Grb2, FLNa) in the regulation of aspects of T-cell signaling including the transcription factor NFkB. In this mini-review, we provide an up-to-date overview of our understanding of the signaling mechanisms that underlie CD28 function and its potential application to the modulation of reactivity to autoimmunity.

Abstract Image

Abstract Image

Abstract Image

适应性免疫应答中的CD28共信号。
t细胞的增殖和功能依赖于抗原受体复合物(TCR/CD3)和各种共受体(如CD28和CTLA-4)的信号。阳性和阴性信号的平衡决定了t细胞对外来和自身抗原反应的结果。CD28在naïve和记忆t细胞反应中是一个重要的共受体。它的阻断作用已被临床用于抑制t细胞对自身抗原的反应。目前的证据表明,CD28既增强了TCR信号传导,又参与了一系列独特的介质(PI3K, Grb2, FLNa),以调节t细胞信号传导的各个方面,包括转录因子NFkB。在这篇综述中,我们对CD28功能的信号机制及其在调节自身免疫反应性方面的潜在应用进行了最新的综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信