Fractal dimension of cervical intraepithelial lesions on cytology smear.

Analytical and quantitative cytology and histology Pub Date : 2010-12-01

Pranab Dey, Nidhi Sharma, Swapan Samanta

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Abstract

Objective: To explore the role of fractal dimension (FD) in distinguishing normal and different grades of cervical intraepithelial lesions.

Study design: We selected 15 cases each of normal samples and low-grade intraepithelial lesions (LSIL) and 14 cases of high-grade intraepithelial lesions (HSIL). All HSIL cases were histopathology proven. The LSIL diagnosis was verified by two cytopathologists. In each case at least 10 abnormal cells were selected in LSIL and HSIL cases and 10 normal cells in normal smears. A total of 202, 157, and 184 cells were selected from the normal, LSIL, and HSIL groups, respectively. The FD was measured in nucleus of each cell by box counting FD method with the help of appropriate software.

Results: The mean FD of the normal, LSIL, and HSIL nucleus was 1.2425 +/- 0.09188, 1.3504 +/- 0.6766, and 1.4379 +/- 0.08830, respectively. An analysis of variance test showed significant difference ofFD among the three groups (p < 0.0001).

Conclusion: FD may be used as an additional factor to distinguish the dysplastic cells in the cervical cytology smear, which may be useful in automated screening in future.

本刊更多论文

宫颈上皮内病变细胞学涂片的分形维数。

目的:探讨分形维数(FD)在区分宫颈上皮内病变正常与不同分级中的作用。研究设计:我们选择正常样本和低级别上皮内病变(LSIL)各15例，高级别上皮内病变(HSIL) 14例。所有HSIL病例均经组织病理学证实。两名细胞病理学家证实了LSIL的诊断。每例LSIL和HSIL至少选择10个异常细胞，正常涂片至少选择10个正常细胞。从正常组、低sil组和HSIL组分别选取202、157和184个细胞。在相应软件的帮助下，采用盒计数FD法测定每个细胞核的FD。结果:正常核、低sil核、HSIL核FD均值分别为1.2425 +/- 0.09188、1.3504 +/- 0.6766、1.4379 +/- 0.08830。方差检验分析显示，三组间ofFD差异有统计学意义(p < 0.0001)。结论:FD可作为鉴别宫颈细胞学涂片中发育不良细胞的附加因素，为今后的自动化筛查提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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