Li Xiao, Guixue Wang, Tao Jiang, Chaojun Tang, Xue Wu, Tin Sun
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引用次数: 7
Abstract
Purpose: The aim of this study was to screen specific adherent matrix for endothelial progenitor cells (EPCs), which can be used for antibody capturing stents.
Methods: In this study, the adhesion of EPCs on different matrices containing three different antibodies, VEGFR-2, CD34, CD133, was observed under shear stress in a flow chamber. Nitric oxide (NO) release, cell proliferation and the retention rate of EPCs, were measured separately.
Results: The results demonstrated that shear stress within a certain range can promote proliferation and NO secretion of EPCs. Under the same shear stress, the EPCs showed stronger adhesion on matrix-containing CD133 antibody than on the other matrices.
Conclusions: CD133 antibody has the potential application for EPCs capture.
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