Synovial sarcoma of the kidney: a report of 4 cases with pathologic appraisal and differential diagnostic review.

Analytical and quantitative cytology and histology Pub Date : 2010-08-01

Yia Swam Tan, Lay Guat Ng, Sidney Kam-Hung Yip, Miah-Hiang Tay, Alvin Soon-Tiong Lim, Sim Leng Tien, Liang Cheng, Puay Hoon Tan

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Abstract

Background: Synovial sarcoma of the kidney is rare. It is clinicoradiologically indistinguishable from the more frequently encountered renal cell carcinoma. Histologically it needs to be differentiated from other spindle cell lesions occurring within the kidney, including a spectrum of benign to malignant tumors. Among malignant spindle cell tumors of the kidney, mimics of synovial sarcoma are sarcomatoid renal cell carcinoma, sarcomatoid urothelial carcinoma and other primary sarcomas, such as leiomyosarcoma and malignant fibrous histiocytoma.

Cases: Four cases of synovial sarcoma originated in the kidney, with this report focusing on clinicopathologic and differential diagnostic features.

Conclusion: The correct diagnosis of synovial sarcoma requires support by an immunohistochemical panel as well as adjunctive investigations like polymerase chain reaction and fluorescence in situ hybridization to determine the presence of the SYT-SSX fusion gene and translocation (X,18), respectively.

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肾滑膜肉瘤:附4例病理鉴定及鉴别诊断复习报告。

背景:肾脏滑膜肉瘤是罕见的。它在临床放射学上与更常见的肾细胞癌难以区分。组织学上，它需要与发生在肾脏内的其他梭形细胞病变区分开来，包括一系列良性到恶性肿瘤。在肾脏恶性梭形细胞肿瘤中，与滑膜肉瘤相似的有类肉瘤肾细胞癌、类肉瘤尿路上皮癌和其他原发肉瘤，如平滑肌肉瘤和恶性纤维组织细胞瘤。病例:4例起源于肾脏的滑膜肉瘤，报告临床病理及鉴别诊断特点。结论:滑膜肉瘤的正确诊断需要免疫组化检查以及聚合酶链反应和荧光原位杂交等辅助检查来确定SYT-SSX融合基因和易位的存在(X,18)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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