"Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous glands.

IF 3.2 4区医学 Q2 PHYSIOLOGY

Pflugers Archiv : European journal of physiology Pub Date : 2011-06-01 Epub Date: 2011-03-08 DOI:10.1007/s00424-011-0941-6

Balázs I Tóth, Attila Oláh, Attila G Szöllosi, Gabriella Czifra, Tamás Bíró

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引用次数: 67

Abstract

The pilosebaceous unit of the human skin consists of the hair follicle and the sebaceous gland. Within this "mini-organ", the sebaceous gland has been neglected by the researchers of the field for several decades. Actually, it was labeled as a reminiscence of human development ("a living fossil with a past but no future"), and was thought to solely act as a producer of sebum, a lipid-enriched oily substance which protects our skin (and hence the body) against various insults. However, due to emerging research activities of the past two decades, it has now become evident that the sebaceous gland is not only a "passive" cutaneous "relic" to establish the physico-chemical barrier function of the skin against constant environmental challenges, but it rather functions as an "active" neuro-immuno-endocrine cutaneous organ. This review summarizes recent findings of sebaceous gland research by mainly focusing on newly discovered physiological functions, novel regulatory mechanisms, key events in the pathology of the gland, and future directions in both experimental and clinical dermatology.

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“皮脂腺细胞的组成”:人类皮脂腺生理学的新机制和概念。

人体皮肤的毛囊皮脂腺单位由毛囊和皮脂腺组成。在这个“微型器官”中，皮脂腺几十年来一直被该领域的研究人员所忽视。事实上，它被贴上了人类发展的标签(“有过去但没有未来的活化石”)，并被认为仅仅是皮脂的生产者，皮脂是一种富含脂质的油性物质，可以保护我们的皮肤(以及身体)免受各种伤害。然而，由于过去二十年的新兴研究活动，现在已经很明显，皮脂腺不仅是一个“被动的”皮肤“遗物”，以建立皮肤的物理-化学屏障功能，以对抗不断的环境挑战，而是一个“主动的”神经-免疫-内分泌皮肤器官。本文综述了近年来皮脂腺的研究进展，重点介绍了皮脂腺的新生理功能、新的调节机制、皮脂腺病理中的关键事件以及皮脂腺实验和临床研究的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pflugers Archiv : European journal of physiology 医学-生理学

CiteScore

8.80

自引率

2.20%

发文量

121

审稿时长

4-8 weeks

期刊介绍： Pflügers Archiv European Journal of Physiology publishes those results of original research that are seen as advancing the physiological sciences, especially those providing mechanistic insights into physiological functions at the molecular and cellular level, and clearly conveying a physiological message. Submissions are encouraged that deal with the evaluation of molecular and cellular mechanisms of disease, ideally resulting in translational research. Purely descriptive papers covering applied physiology or clinical papers will be excluded. Papers on methodological topics will be considered if they contribute to the development of novel tools for further investigation of (patho)physiological mechanisms.