Pancreas organogenesis: From bud to plexus to gland

IF 2 3区 生物学 Q2 ANATOMY & MORPHOLOGY
Fong Cheng Pan, Chris Wright
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引用次数: 558

Abstract

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell-types in vivo, and to the optimization of the forward-directed-differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature β-cells. Developmental Dynamics 240:530–565, 2011. © 2011 Wiley-Liss, Inc.

Abstract Image

胰腺器官发生:从芽到丛到腺
胰腺器官发生包括信号事件和转录网络的协调和高度复杂的相互作用,指导器官发育的阶梯过程,从早期芽化一直到最终成熟的器官状态。在过去的几年里,对胰腺发育的广泛研究在很大程度上是由胰腺疾病(糖尿病、胰腺癌等)的转化潜力驱动的,显著地提高了我们对这些过程的认识。这是一个可以实现的目标,我们将有一天对控制整个器官遗传过程的转录和信号编码有一个清晰、完整的了解,使我们能够将这些知识应用于治疗环境,通过在体外产生替代细胞,或者有一天应用于体内的整个器官。这篇综述总结了过去5年的发现,我们认为这些发现对深入了解胰腺发育有重要意义。我们没有试图全面地涵盖所有方面,而是选择突出有趣的新概念,并讨论一些更有争议的发现或建议。在回顾的最后,我们包括了一个关于整个胰腺分化过程如何能够以一种受调节的方式展开或重定向的观点部分,并提出了与体内其他胰腺细胞类型的可能重编程的联系,以及与人类胚胎干细胞(hESC)或诱导多能细胞(iPSC)向成熟β细胞的正向分化的优化。科学通报,2011(4):531 - 531。©2011 Wiley-Liss, Inc。
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来源期刊
Developmental Dynamics
Developmental Dynamics 生物-发育生物学
CiteScore
5.10
自引率
8.00%
发文量
116
审稿时长
3-8 weeks
期刊介绍: Developmental Dynamics, is an official publication of the American Association for Anatomy. This peer reviewed journal provides an international forum for publishing novel discoveries, using any model system, that advances our understanding of development, morphology, form and function, evolution, disease, stem cells, repair and regeneration.
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