Live Imaging of Early Developmental Processes in Mammalian Embryos with Optical Coherence Tomography.

IF 2.3 3区医学 Q2 OPTICS

Journal of Innovative Optical Health Sciences Pub Date : 2009-01-01 DOI:10.1142/S1793545809000619

Kirill V Larin, Irina V Larina, Michael Liebling, Mary E Dickinson

引用次数: 53

Abstract

Early embryonic imaging of cardiovascular development in mammalian models requires a method that can penetrate through and distinguish the many tissue layers with high spatial and temporal resolution. In this paper we evaluate the capability of Optical Coherence Tomography (OCT) technique for structural 3D embryonic imaging in mouse embryos at different stages of the developmental process ranging from 7.5 dpc up to 10.5 dpc. Obtained results suggest that the collected data is suitable for quantitative and qualitative measurements to assess cardiovascular function in mouse models, which is likely to expand our knowledge of the complexity of the embryonic heart, and its development into an adult heart.

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光学相干断层成像在哺乳动物胚胎早期发育过程中的实时成像。

哺乳动物模型心血管发育的早期胚胎成像需要一种能够以高空间和时间分辨率穿透和区分许多组织层的方法。在本文中，我们评估了光学相干断层扫描(OCT)技术在发育过程中不同阶段(从7.5 dpc到10.5 dpc)的小鼠胚胎结构三维成像的能力。所获得的结果表明，所收集的数据适用于定量和定性测量，以评估小鼠模型的心血管功能，这可能会扩大我们对胚胎心脏及其发育成成人心脏的复杂性的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Innovative Optical Health Sciences OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.50

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： JIOHS serves as an international forum for the publication of the latest developments in all areas of photonics in biology and medicine. JIOHS will consider for publication original papers in all disciplines of photonics in biology and medicine, including but not limited to: -Photonic therapeutics and diagnostics- Optical clinical technologies and systems- Tissue optics- Laser-tissue interaction and tissue engineering- Biomedical spectroscopy- Advanced microscopy and imaging- Nanobiophotonics and optical molecular imaging- Multimodal and hybrid biomedical imaging- Micro/nanofabrication- Medical microsystems- Optical coherence tomography- Photodynamic therapy. JIOHS provides a vehicle to help professionals, graduates, engineers, academics and researchers working in the field of intelligent photonics in biology and medicine to disseminate information on the state-of-the-art technique.