Advances in nitric oxide-releasing hydrogels for biomedical applications

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science Pub Date : 2023-08-01 DOI:10.1016/j.cocis.2023.101704

Lori M. Estes Bright, Yi Wu, Elizabeth J. Brisbois, Hitesh Handa

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引用次数: 1

Abstract

Hydrogels provide a plethora of advantages to biomedical treatments due to their highly hydrophilic nature and tissue-like mechanical properties. Additionally, the numerous and widespread endogenous roles of nitric oxide have led to an eruption in research developing biomimetic solutions to the many challenges the biomedical world faces. Though many design factors and fabrication details must be considered, utilizing hydrogels as nitric oxide delivery vehicles provides promising materials in several applications. Such applications include cardiovascular therapy, vasodilation and angiogenesis, antimicrobial treatments, wound dressings, and stem cell research. Herein, a recent update on the progress of NO-releasing hydrogels is presented in depth. In addition, considerations for the design and fabrication of hydrogels and specific biomedical applications of nitric oxide-releasing hydrogels are discussed.

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生物医学用一氧化氮释放水凝胶研究进展

水凝胶由于其高度亲水性和类似组织的机械性能，为生物医学治疗提供了大量的优势。此外，一氧化氮的众多和广泛的内源性作用导致了研究开发仿生解决方案的爆发，以应对生物医学世界面临的许多挑战。尽管必须考虑许多设计因素和制造细节，但利用水凝胶作为一氧化氮输送载体在许多应用中提供了有前途的材料。这些应用包括心血管治疗、血管扩张和血管生成、抗菌治疗、伤口敷料和干细胞研究。在此，最近更新的进展的no释放水凝胶是深入介绍。此外，还讨论了水凝胶的设计和制造以及一氧化氮释放水凝胶的特定生物医学应用。

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来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.