[Contribution of various MRI techniques to the characterization of Mild cognitive impairment].

Caroline Baclet-Roussel, Joël Ankri, Anne-Marie Ergis
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引用次数: 2

Abstract

Mild cognitive impairment (MCI) is considered as a strong risk factor for Alzheimer's disease (AD) or other dementia syndromes. Since the last decade, numerous publications have been aimed to characterize early detectable brain changes in vivo, using more and more efficient neuroimaging techniques. This review is devoted to the brain damages detectable in MCI patients according to the MRI techniques available to date. The greatest number of studies, using structural and functional imaging, report many abnormalities principally located in the medial temporal lobe. They show, especially in this region, cortical atrophy, reduction of glucose metabolism, decrease in regional cerebral blood flew and biochemical changes. Moreover, progresses in the functional methods allow to detect brain activity during memory tasks, trying to specify whether this activity increases or decreases according to the task and the severity of cognitive impairment. The contribution of each RMI technique (morphologic, metabolic, and functional) is addressed in order to reveal how relevant they are to distinguish subjects with MCI from patients with early AD. Furthermore, their relevance to discriminate between MCI with different degrees of cognitive deficit and their power to predict the risk of conversion to AD is discussed. Finally, we review the main assumptions made to explain the underlying mechanisms of cognitive decline and present evidences in favor of dynamic compensatory processes, existence of cognitive reserve and disconnection processes. Many neuroimaging data support the pattern of installation and evolution of brain damages found in AD, reinforcing the idea that a part of amnesic MCI is probably a prodromal state of AD.

[各种MRI技术对轻度认知障碍表征的贡献]。
轻度认知障碍(MCI)被认为是阿尔茨海默病(AD)或其他痴呆综合征的一个重要危险因素。自过去十年以来,许多出版物都旨在描述体内早期可检测的大脑变化,使用越来越高效的神经成像技术。本综述致力于根据迄今为止可用的MRI技术在MCI患者中检测到的脑损伤。使用结构和功能成像的大量研究报告了许多主要位于内侧颞叶的异常。它们显示,特别是在这个区域,皮质萎缩,葡萄糖代谢减少,区域脑血流量减少和生化变化。此外,功能方法的进步允许检测记忆任务期间的大脑活动,并试图根据任务和认知障碍的严重程度确定这种活动是增加还是减少。本文讨论了每种RMI技术(形态学、代谢和功能)的贡献,以揭示它们在区分MCI患者和早期AD患者方面的相关性。此外,我们还讨论了它们与区分不同程度认知缺陷的轻度认知损伤的相关性,以及它们预测转化为AD风险的能力。最后,我们回顾了解释认知衰退潜在机制的主要假设,并提出了支持动态补偿过程、认知储备和断开过程存在的证据。许多神经影像学数据支持阿尔茨海默病中发现的脑损伤的安装和进化模式,加强了失忆性轻度认知损伤的一部分可能是阿尔茨海默病前驱状态的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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