Change in Hemoglobin A1c and C-Reactive Protein Levels in Patients With Diabetes Mellitus

Journal of the cardiometabolic syndrome Pub Date : 2009-04-13 DOI:10.1111/j.1559-4572.2008.00042.x

Sameed Ahmed M. Khatana BS, Tracey H. Taveira PharmD, Gaurav Choudhary MD, Charles B. Eaton MD, Wen-Chih Wu MD

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引用次数: 4

Abstract

The authors studied the effects on C-reactive protein (CRP) levels of an intensive intervention to reduce hemoglobin A_1c (HbA_1c) among 58 veterans with type 2 diabetes. Weekly group sessions of behavioral and pharmacologic intervention were conducted for 4 weeks at Providence Veterans Affairs Medical Center. Change in cardiovascular risk factors and CRP levels were compared at baseline and 3 months postintervention. There was a significant decrease in HbA_1c (−0.7%±1.9%, P<.01), total cholesterol (−20.3±41.1 mg/dL, P=.01), low-density lipoprotein cholesterol (−11.7±31.4 mg/dL, P=.05), systolic blood pressure (−6.9±21.2 mm Hg, P=.03), and diastolic blood pressure (−6.0±10.6 mm Hg, P<.01) over 4 months. There was no significant change in CRP levels (1.1±6.6 mg/L, P=.2). These results suggest that CRP effects may not be adequate to predict changes in cardiovascular risk among diabetic patients and should not be a surrogate for achieving evidence-based goals in traditional cardiovascular risk factors.

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糖尿病患者血红蛋白A1c和c反应蛋白水平的变化

作者研究了对58名2型糖尿病退伍军人进行强化干预以降低血红蛋白A1c (HbA1c)对c反应蛋白(CRP)水平的影响。在普罗维登斯退伍军人事务医疗中心进行了为期4周的每周行为和药物干预小组会议。在基线和干预后3个月比较心血管危险因素和CRP水平的变化。4个月内，患者糖化血红蛋白(- 0.7%±1.9%，P= 0.01)、总胆固醇(- 20.3±41.1 mg/dL, P= 0.01)、低密度脂蛋白胆固醇(- 11.7±31.4 mg/dL, P= 0.05)、收缩压(- 6.9±21.2 mm Hg, P= 0.03)、舒张压(- 6.0±10.6 mm Hg, P= 0.01)均显著降低。CRP水平无显著变化(1.1±6.6 mg/L, P= 0.2)。这些结果表明，CRP效应可能不足以预测糖尿病患者心血管风险的变化，也不应作为实现传统心血管危险因素循证目标的替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the cardiometabolic syndrome

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