Purinergic regulation of vascular tone and remodelling

G. Burnstock
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引用次数: 103

Abstract

1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.

2 There is dual control of vascular tone by adenosine 5′-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia.

3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation.

4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.

嘌呤能调节血管张力和血管重构
嘌呤能信号既参与血管张力的短期控制,也参与血管重构过程中细胞增殖、迁移和死亡的长期控制。血管张力受血管周围神经释放的5 ' -三磷酸腺苷(ATP)和内皮细胞响应血流变化(剪切应力)和缺氧释放的ATP的双重控制。ATP及其分解产物腺苷调节平滑肌和内皮细胞的增殖。这些调节机制在病理条件下很重要,包括高血压、动脉粥样硬化、再狭窄、糖尿病和血管疼痛。
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