Molecular imaging of tumor metabolism and apoptosis.

U Haberkorn, A Altmann, W Mier, M Eisenhut
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引用次数: 0

Abstract

Increased metabolism has been found to be one of the most prominent features of malignant tumors. This property led to the development of tracers for the assessment of glucose metabolism and amino acid transport and their application for tumor diagnosis and staging. Prominent examples are fluorodeoxyglucose, methionine and tyrosine analogs, which have found broad clinical application. Since quantitative procedures are available, these techniques can also be used for therapy monitoring. Another approach may be based on the noninvasive detection of apoptosis with tracers for phosphatidyl-serine presentation and/or caspase activation as surrogate markers for therapeutic efficacy. Finally, the evaluation of hypoxia with nitroimidazoles may be a valuable tool for prognosis and therapy planning.

肿瘤代谢与凋亡的分子影像学研究。
新陈代谢增加已被发现是恶性肿瘤最显著的特征之一。这一特性促使示踪剂的发展,用于评估葡萄糖代谢和氨基酸运输及其在肿瘤诊断和分期中的应用。突出的例子是氟脱氧葡萄糖、蛋氨酸和酪氨酸类似物,它们已经发现了广泛的临床应用。由于定量程序是可用的,这些技术也可用于治疗监测。另一种方法可能是基于无创检测细胞凋亡,用磷脂酰丝氨酸呈现和/或半胱天冬酶激活的示踪剂作为治疗效果的替代标志物。最后,评估硝基咪唑对缺氧的影响可能是一个有价值的预后和治疗计划的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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